Product image of Metronidazol Bradex (Metronidazole) supplied by GNH India

Metronidazol Bradex

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Bradex (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Bradex, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal diseases in adult and pediatric patients when indicated by a prescriber.

GNH India supplies Metronidazol Bradex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Bradex S.A.

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Indications & Clinical Uses

Metronidazol Bradex is a nitroimidazole antibiotic used to target anaerobic microorganisms and protozoa.

  • Anaerobic bacterial infections: eradicates mixed anaerobic flora, reducing infection severity.
  • Amoebiasis: eliminates Entamoeba histolytica trophozoites, aiding resolution of intestinal disease.
  • Bacterial vaginosis: restores normal vaginal flora by suppressing anaerobic overgrowth.
  • Clostridioides difficile infection: controls toxin‑producing anaerobes in the colon.
  • Trichomoniasis: destroys Trichomonas vaginalis, relieving symptoms and preventing transmission.

How It Works

  • Metronidazole enters anaerobic cells by passive diffusion and is reduced by microbial ferredoxin proteins. The reduced form generates reactive nitro radicals that damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to cell death in susceptible anaerobic bacteria and protozoa.

Side Effects

Metronidazol Bradex may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient alteration of taste perception.
  • Headache: occasional dull or throbbing pain.
  • Diarrhea: loose stools that may be self‑limiting.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Peripheral neuropathy: tingling or numbness, especially with prolonged use.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Pancytopenia: reduction in blood cell counts.

Precautions & Warnings

Before using Metronidazol Bradex, consider the following safety measures.

  • Renal impairment: adjust therapy if kidney function is reduced.
  • Hepatic impairment: monitor liver function tests during treatment.
  • Alcohol consumption: avoid alcohol to prevent disulfiram‑like reactions.
  • Pregnancy: use only if potential benefit justifies potential risk; data are limited.
  • Lactation: weigh benefits against possible infant exposure.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Metronidazol Bradex can interact with several medicines.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, and tachycardia.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: heightened lithium toxicity, monitor serum levels.

Moderate Interactions (Monitor Closely)

  • Phenytoin: reduced phenytoin concentrations, may require dose adjustment.
  • Cimetidine: increased metronidazole plasma levels, watch for toxicity.

Frequently Asked Questions

Metronidazol Bradex is an intravenous formulation of metronidazole indicated for the treatment of anaerobic bacterial infections, amoebiasis, bacterial vaginosis, Clostridioides difficile infection, and trichomoniasis. It is prescribed when these infections are confirmed or strongly suspected and when oral therapy is not appropriate.

Metronidazole is reduced inside anaerobic microorganisms, forming nitro radicals that damage DNA and inhibit nucleic acid synthesis. This disruption leads to loss of cellular function and ultimately death of the susceptible bacteria or protozoa.

The specific dose and duration of Metronidazol Bradex are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other individual factors. No standard dosing is provided here.

Safety data for Metronidazol Bradex in pregnancy are limited, and the product is classified as pregnancy category unknown. It should be used only if the potential benefit outweighs the potential risk. Breastfeeding mothers should consult a healthcare professional, as the drug may be excreted in milk.

To order Metronidazol Bradex, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Metronidazol Bradex delivers metronidazole intravenously, offering rapid systemic exposure compared with oral nitroimidazoles such as tinidazole or ornidazole. IV administration is advantageous for severe infections, patients unable to take oral medication, or when high plasma concentrations are required quickly.

Metronidazol Bradex must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before administration, inspect for particulate matter and ensure the solution is at room temperature if required by the clinical protocol.

Metronidazol Bradex is given by intravenous infusion or injection under the supervision of a qualified healthcare professional. The infusion rate and dilution are determined by the prescriber and institutional guidelines to achieve the desired therapeutic concentration while minimizing adverse effects.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions (including anaphylaxis), Stevens‑Johnson syndrome, hepatotoxicity, and pancytopenia. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and blood count alterations throughout therapy.

Metronidazol Bradex should be avoided in patients with known hypersensitivity to metronidazole or other nitroimidazoles, those with severe hepatic impairment where benefit does not outweigh risk, and individuals who cannot abstain from alcohol during treatment due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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