Product image of Metronidazol Braun (Metronidazole) supplied by GNH India

Metronidazol Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Braun, is a Nitroimidazole antibiotic presented as an intravenous solution for Intravenous use. It treats anaerobic bacterial and protozoal infections in adult patients.

GNH India supplies Metronidazol Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Anaerobic bacterial infections: eradicates susceptible anaerobes and helps resolve tissue infection.
  • Trichomoniasis, amoebiasis, giardiasis: eliminates the protozoal organisms responsible for gastrointestinal and genitourinary disease.
  • Bacterial vaginosis: reduces pathogenic anaerobes to restore normal vaginal flora.

How It Works

  • Metronidazole enters anaerobic microorganisms and is reduced by their electron transport proteins to generate nitro radicals. These reactive species damage DNA and inhibit nucleic acid synthesis, leading to cell death of susceptible bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: mild to moderate headache.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: crampy discomfort.
  • Dizziness: light‑headed feeling.

Serious or Rare Side Effects

  • Seizures: convulsive episodes, especially with high plasma levels.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reaction (anaphylaxis): rash, swelling, airway compromise.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for adverse events.

  • Renal impairment: adjust dose or monitor plasma concentrations.
  • Hepatic impairment: use with caution and monitor liver function tests.
  • Alcohol consumption: avoid to prevent disulfiram‑like reaction.
  • Concomitant warfarin: monitor INR closely for enhanced anticoagulation.
  • Pregnancy: prescribe only if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Metronidazole can interact with several medicines, requiring either avoidance or careful monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing and vomiting.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, risking toxicity.
  • CYP450 inhibitors (e.g., cimetidine): increase metronidazole concentrations.
  • Disulfiram: additive disulfiram‑like reactions.

Moderate Interactions (Monitor Closely)

  • Phenytoin: reduces metronidazole levels, possibly decreasing efficacy.
  • Carbamazepine: lowers metronidazole concentrations.
  • Rifampin: induces metabolism, reducing drug exposure.
  • Theophylline: may increase theophylline levels.
  • Oral contraceptives: may reduce contraceptive effectiveness.

Frequently Asked Questions

Metronidazol Braun contains metronidazole and is indicated for the treatment of anaerobic bacterial infections, protozoal infections such as trichomoniasis, amoebiasis and giardiasis, and bacterial vaginosis. It is administered intravenously in hospital or clinical settings to eradicate susceptible microorganisms.

Metronidazole is taken up by anaerobic microorganisms and reduced by their electron transport proteins. This reduction creates nitro radicals that damage microbial DNA and inhibit nucleic acid synthesis, leading to cell death of the targeted bacteria and protozoa.

The dose of Metronidazol Braun is determined by the prescribing clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here; the prescriber sets the appropriate dosing schedule.

Safety data for metronidazole in pregnancy and lactation are limited. It should be used during pregnancy only when the potential benefit justifies the potential risk to the fetus, and breastfeeding mothers should discuss risks with their healthcare provider, as the drug can be excreted in breast milk.

To order Metronidazol Braun, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Metronidazol Braun offers a broad spectrum against obligate anaerobes and certain protozoa, whereas alternatives such as clindamycin or beta‑lactam/beta‑lactamase inhibitor combinations may lack antiprotozoal activity. Choice of therapy depends on infection site, susceptibility patterns, patient tolerance and potential drug interactions.

Metronidazol Braun should be stored at 2‑8 °C (refrigerated). Keep the vials in the original packaging, protect them from light, and do not freeze or shake the solution. If the product reaches room temperature for a short period, it may still be used, but it should be returned to refrigeration promptly.

Metronidazol Braun is given by intravenous infusion. The solution is typically diluted in compatible IV fluids and infused over a period determined by the prescriber, often 30‑60 minutes. Administration should follow aseptic technique and institutional infusion guidelines.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatic toxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin reactions, liver function changes, and signs of bleeding, especially when combined with anticoagulants.

Metronidazol Braun is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is advised in individuals with severe hepatic or renal impairment, those receiving disulfiram, and patients with a history of seizures or peripheral neuropathy until evaluated by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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