Product image of Metronidazol/Espiramicina Farmalider (Spiramycin, Metronidazole) supplied by GNH India

Metronidazol/Espiramicina Farmalider

Active Ingredient:
Spiramycin, Metronidazole
Origin:
EU

Metronidazol/Espiramicina Farmalider (Spiramycin, Metronidazole)

Spiramycin, the active ingredient in Metronidazol/Espiramicina Farmalider, is a macrolide antibiotic combined with Metronidazole, a nitroimidazole, presented for oral administration. The combination treats bacterial infections responsive to macrolides, anaerobic infections, and provides prophylaxis against toxoplasmosis in susceptible individuals and is often prescribed by infectious disease specialists.

GNH India supplies Metronidazol/Espiramicina Farmalider as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, providing reliable product quality, regulatory compliance, and timely delivery to meet local and regional health system demands.

Manufacturer / TM Owner

Farmalider, S.A.

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Indications & Clinical Uses

Metronidazol/Espiramicina is used to treat bacterial and protozoal infections where both macrolide and nitroimidazole activity are required.

  • Bacterial infections susceptible to macrolides: Effective against Gram‑positive and atypical bacteria resistant to other classes.
  • Anaerobic infections: Targets obligate anaerobes such as Bacteroides and Clostridium species.
  • Toxoplasmosis prophylaxis: Prevents congenital transmission in pregnant women and infection in immunocompromised patients.

How It Works

  • Metronidazole penetrates anaerobic microorganisms and is reduced to reactive metabolites that cleave DNA, leading to cell death. Spiramycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking translocation and inhibiting protein synthesis. This dual mechanism allows simultaneous eradication of aerobic and anaerobic pathogens while also interfering with protozoal replication.

Side Effects

Metronidazol/Espiramicina may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools that may be watery.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: mild headache.
  • Vomiting: occasional episodes of vomiting.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Seizures: rare neurologic events, especially with high doses.
  • Liver toxicity: elevated liver enzymes or jaundice.
  • Neutropenia: low white blood cell count.
  • Pseudomembranous colitis: severe colitis due to Clostridioides difficile infection.

Precautions & Warnings

Before prescribing Metronidazol/Espiramicina, clinicians should consider several safety precautions.

  • Assess allergy history: verify no known hypersensitivity to macrolides or nitroimidazoles.
  • Monitor liver function: check baseline enzymes and repeat during therapy.
  • Evaluate renal function: adjust dose in severe impairment if needed.
  • Avoid alcohol: concurrent intake may cause disulfiram‑like reactions.
  • Pregnancy and lactation: use only if benefits outweigh risks after professional assessment.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Metronidazol/Espiramicina can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Disulfiram: may cause severe flushing and hypotension.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Cyclosporine: elevated levels leading to nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced effectiveness, advise backup method.
  • Phenytoin: altered metabolism, monitor seizure control.
  • Lithium: increased lithium levels, monitor for toxicity.

Frequently Asked Questions

Metronidazol/Espiramicina is a prescription combination of spiramycin and metronidazole used to treat bacterial infections that respond to macrolides, anaerobic infections, and to provide prophylaxis against toxoplasmosis in at‑risk patients such as pregnant women or immunocompromised individuals.

Spiramycin binds to the bacterial 50S ribosomal subunit, blocking protein synthesis, while metronidazole enters anaerobic cells and is reduced to reactive metabolites that break DNA strands. The dual action offers broad antibacterial coverage and antiprotozoal activity against organisms like Toxoplasma gondii.

The dosage and treatment duration are determined by the prescribing healthcare professional based on the specific infection, patient weight, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety in pregnancy and lactation has not been fully established. The product should be used only when the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other combination products, Metronidazol/Espiramicina uniquely pairs a macrolide (spiramycin) with a nitroimidazole (metronidazole), offering simultaneous activity against aerobic, anaerobic bacteria and certain protozoa. This can reduce the need for multiple separate agents, but choice of therapy should be guided by susceptibility patterns and clinical guidelines.

The product should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. No refrigeration is required for this oral formulation.

Metronidazol/Espiramicina is taken orally, usually with a full glass of water. The exact dosing schedule, such as frequency and duration, is prescribed by a healthcare professional and should be adhered to for optimal efficacy.

Serious risks include severe allergic reactions (anaphylaxis), seizures, liver toxicity, neutropenia, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they experience symptoms such as rash, difficulty breathing, persistent vomiting, jaundice, or severe abdominal pain.

Individuals with known hypersensitivity to spiramycin, other macrolides, metronidazole, or any component of the formulation should avoid this medication. It is also contraindicated in patients with a history of severe liver disease or those who are currently taking disulfiram.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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