Product image of Metronidazol Isab (Metronidazole) supplied by GNH India

Metronidazol Isab

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Isab (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Isab, is a nitroimidazole presented as an injection for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in adults and children as prescribed.

GNH India supplies Metronidazol Isab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Metronidazole is employed to manage infections caused by anaerobic bacteria and susceptible protozoa.

  • Anaerobic bacterial infections: eradicates susceptible anaerobes, reducing tissue damage and systemic spread.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating over‑growth of anaerobic organisms.
  • Trichomoniasis: kills Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Amoebiasis: eliminates Entamoeba histolytica trophozoites in intestinal and extra‑intestinal disease.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile, aiding clinical recovery.

How It Works

  • Metronidazole enters susceptible microorganisms and is reduced by intracellular electron transport proteins to form nitro radical anions. These reactive intermediates damage DNA and inhibit nucleic acid synthesis, leading to cell death in anaerobic bacteria and certain protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: mild to moderate headache.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Severe allergic reactions: rash, swelling, anaphylaxis.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Neutropenia: reduced white blood cell count.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for adverse events.

  • Renal function assessment: adjust therapy in impaired clearance.
  • Hepatic function monitoring: watch for liver enzyme elevations.
  • Alcohol avoidance: prevent disulfiram‑like reactions.
  • Pregnancy safety: use only if benefits outweigh risks.
  • Hypersensitivity evaluation: discontinue if allergic signs appear.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metronidazole can interact with several medicines, requiring caution.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: can raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Carbamazepine: may reduce metronidazole effectiveness.
  • Oral contraceptives: may diminish contraceptive efficacy, requiring additional protection.

Frequently Asked Questions

Metronidazol Isab, containing metronidazole, is indicated for anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amoebiasis, and Clostridioides difficile infection. It is prescribed by a qualified health professional based on the specific infection and patient characteristics.

Metronidazole is taken up by susceptible anaerobic bacteria and protozoa, where intracellular reduction creates nitro radical anions. These reactive species damage DNA and inhibit nucleic acid synthesis, leading to microbial cell death while sparing most aerobic cells.

The dosage of Metronidazol Isab is determined by the prescribing clinician according to the infection type, severity, patient weight, renal and hepatic function, and local guidelines. Patients should follow the exact regimen provided by their health‑care provider.

Safety data for metronidazole in pregnancy are limited, and the drug should be used only if the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult their physician, as metronidazole can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms and certain protozoa, offering rapid bactericidal activity. Compared with broad‑spectrum beta‑lactams, it provides a narrower spectrum focused on anaerobes, often with fewer drug‑resistance concerns, but it lacks activity against aerobic Gram‑positive cocci.

Metronidazol Isab should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keeping the product in its original packaging helps maintain stability and potency throughout its shelf life.

Metronidazol Isab is supplied as a sterile injection for intravenous infusion. It is administered by a qualified health‑care professional under aseptic conditions, typically diluted in compatible IV fluids and infused over the prescribed period.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as Stevens‑Johnson syndrome, hepatic toxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and blood count alterations during therapy.

Metronidazol Isab is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles. Caution is also advised for patients with severe hepatic impairment, those receiving disulfiram, and patients with a history of seizures or neuropathy unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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