Product image of Metronidazol Noridem (Metronidazole) supplied by GNH India

Metronidazol Noridem

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Noridem (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Noridem, is a nitroimidazole antibiotic presented as an injection for intravenous use. It treats anaerobic bacterial infections and certain protozoal diseases in adult patients.

GNH India supplies Metronidazol Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Metronidazol Noridem is a nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and susceptible protozoa.

  • Anaerobic bacterial infections: effective against infections caused by susceptible anaerobic organisms.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes.
  • Trichomoniasis: eradicates Trichomonas vaginalis in affected patients.
  • Amoebiasis: treats intestinal and extra‑intestinal infections caused by Entamoeba histolytica.
  • Intra‑abdominal infections: combats mixed aerobic‑anaerobic infections following surgery or perforation.
  • Septicemia caused by susceptible organisms: provides systemic coverage for bloodstream infections.

How It Works

  • Metronidazole enters susceptible anaerobic bacteria and protozoa, where intracellular reduction of its nitro group generates reactive nitro radicals. These metabolites damage DNA, inhibit nucleic acid synthesis, and lead to cell death, selectively targeting organisms that thrive in low‑oxygen environments.

Side Effects

Metronidazol Noridem may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional mild to moderate headache.
  • Diarrhea: loose stools that may be self‑limiting.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: anaphylaxis or angioedema requiring emergency care.

Precautions & Warnings

Use Metronidazol Noridem with attention to patient‑specific factors and safety measures.

  • Renal impairment: assess kidney function and adjust therapy if necessary.
  • Hepatic dysfunction: monitor liver enzymes during treatment.
  • Alcohol consumption: avoid alcohol to prevent disulfiram‑like reactions.
  • Pregnancy: prescribe only when benefits outweigh potential risks.
  • Concurrent warfarin therapy: monitor INR closely for increased anticoagulation.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Metronidazol Noridem can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: may cause severe disulfiram‑like reaction.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: elevated lithium concentrations, risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma levels.
  • Phenytoin: may reduce metronidazole efficacy, requiring therapeutic monitoring.

Frequently Asked Questions

Metronidazol Noridem is indicated for a range of anaerobic bacterial infections and protozoal diseases, including intra‑abdominal infections, bacterial vaginosis, trichomoniasis, amoebiasis, and septicemia caused by susceptible organisms. It is administered intravenously to provide systemic coverage in hospitalized patients.

Metronidazole penetrates susceptible anaerobic microbes and protozoa, where enzymatic reduction of its nitro group creates reactive radicals. These radicals damage microbial DNA and inhibit nucleic acid synthesis, leading to cell death while sparing most aerobic human cells.

The dosage of Metronidazol Noridem is determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and local guidelines. Healthcare professionals set the appropriate dose and infusion rate for each individual case.

The safety of Metronidazol Noridem in pregnancy has not been definitively established, and it is classified as a Category unknown. It should be used only when the potential benefits justify any potential risk to the fetus. Breastfeeding mothers should consult their physician, as metronidazole can be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Metronidazol Noridem shares the same class mechanism as other nitroimidazoles such as tinidazole, but it is formulated for intravenous administration, offering rapid systemic exposure suitable for severe infections. Oral nitroimidazoles are used for milder cases, whereas the IV form ensures higher plasma concentrations for critical care settings.

Metronidazol Noridem should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Do not freeze the product. Before use, inspect the vial for particulate matter and ensure aseptic technique during preparation.

The product is supplied as a sterile solution for intravenous injection. It is administered by a healthcare professional via a controlled infusion, typically diluted in compatible IV fluids according to the prescribing information and patient-specific dosing instructions.

Serious risks include seizures, peripheral neuropathy, and severe allergic reactions such as anaphylaxis. Patients should be monitored for neurologic symptoms, skin rash, or breathing difficulties, and treatment should be discontinued immediately if any of these events occur.

Metronidazol Noridem is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. Caution is also advised for individuals with severe hepatic impairment, and it should be avoided in patients who have consumed alcohol within 24 hours due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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