Product image of Metronidazol Noridem (Metronidazole) supplied by GNH India

Metronidazol Noridem

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Noridem (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Noridem, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats anaerobic bacterial and protozoal infections in adults and children as prescribed.

GNH India supplies Metronidazol Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Metronidazole is employed to manage infections caused by anaerobic bacteria and certain protozoa.

  • Bacterial vaginosis: eliminates anaerobic organisms and restores normal vaginal flora.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Amoebic dysentery: kills Entamoeba histolytica trophozoites in intestinal tissue.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile strains.
  • Anaerobic bacterial infections: targets a broad range of anaerobes in intra‑abdominal, pelvic, and soft‑tissue sites.

How It Works

  • Metronidazole penetrates anaerobic microorganisms and is reduced by intracellular ferredoxin proteins. The reduced form binds to DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to cell death in susceptible bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: transient gastrointestinal upset.
  • Metallic taste: persistent metallic sensation in the mouth.
  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: cramping or discomfort.

Serious or Rare Side Effects

  • Seizures: neurological events requiring immediate attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane involvement.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Neutropenia: reduced white blood cell count increasing infection risk.

Precautions & Warnings

Metronidazole requires careful consideration of patient‑specific factors before use.

  • Renal impairment: assess kidney function and adjust dosing if needed.
  • Hepatic dysfunction: monitor liver enzymes during therapy.
  • Alcohol consumption: avoid alcohol to prevent a disulfiram‑like reaction.
  • Pregnancy: use only when benefits outweigh potential risks.
  • Concurrent anticoagulants: monitor for enhanced bleeding tendency.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe disulfiram‑like reaction.
  • Warfarin: can increase anticoagulant effect and bleeding risk.
  • Lithium: may raise lithium levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma concentrations.
  • Phenobarbital: can reduce metronidazole effectiveness.
  • Oral contraceptives: may decrease hormonal contraceptive efficacy.

Frequently Asked Questions

Metronidazol Noridem is an intravenous formulation of metronidazole used for bacterial vaginosis, trichomoniasis, amoebic dysentery, Clostridioides difficile infection, and other anaerobic bacterial infections. It is prescribed by a qualified health professional based on the specific infection being treated.

Metronidazole enters anaerobic microorganisms and is reduced by intracellular proteins. The reduced drug binds to DNA, causing strand breakage and inhibiting nucleic acid synthesis, which ultimately leads to cell death of susceptible bacteria and protozoa.

The dosage of Metronidazol Noridem is determined by the prescribing clinician according to the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here.

Safety in pregnancy and lactation has not been fully established. It should be used only when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Metronidazol Noridem contains the same active ingredient as other metronidazole products but is supplied as a sterile injectable solution, allowing rapid systemic exposure. Compared with oral formulations, the IV route is preferred for severe or gastrointestinal‑unabsorbed infections, providing higher plasma concentrations more quickly.

The product should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep it in the original packaging until ready for use to maintain stability.

Metronidazol Noridem is administered intravenously by a qualified health professional. The solution is diluted in an appropriate compatible IV fluid and infused over the period recommended by the prescriber, usually ranging from 30 minutes to several hours depending on the indication.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatotoxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and blood count alterations during therapy.

Metronidazol Noridem is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. Caution is also advised for individuals with severe hepatic impairment, those receiving disulfiram, or patients with a history of seizures unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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