Product image of Metronidazol Noridem (Metronidazole) supplied by GNH India

Metronidazol Noridem

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Noridem (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Noridem, is a nitroimidazole antibiotic presented as an intravenous solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal diseases in adults and children as prescribed.

GNH India supplies Metronidazol Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

  • Metronidazole is employed to combat infections caused by anaerobic bacteria and susceptible protozoa.
  • Anaerobic bacterial infections: eliminates susceptible anaerobic organisms and reduces infection severity.
  • Bacterial vaginosis: restores normal vaginal flora by targeting anaerobic pathogens.
  • Trichomoniasis: eradicates Trichomonas vaginalis in affected patients.
  • Amoebic dysentery: treats intestinal infection caused by Entamoeba histolytica.
  • Clostridioides difficile infection: reduces toxin‑producing bacteria and helps resolve colitis.

How It Works

  • Metronidazole enters susceptible anaerobic cells and is reduced by microbial nitroreductases, forming reactive nitro radicals that bind to DNA and other macromolecules, disrupting DNA synthesis and leading to cell death of anaerobic bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional mild headache.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: feeling light‑headed.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Stevens‑Johnson syndrome: severe skin rash.
  • Liver toxicity: elevated liver enzymes or hepatitis.
  • Neutropenia: reduced white blood cell count.

Precautions & Warnings

  • Metronidazole requires careful use in specific patient groups.
  • Assess renal function: adjust dosing in severe renal impairment.
  • Monitor liver enzymes: use caution in hepatic disease.
  • Avoid alcohol: risk of disulfiram‑like reaction.
  • Pregnancy: prescribe only if benefits outweigh potential risks.
  • Use in pediatric patients: dose based on weight and indication.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Metronidazole can interact with several medicines, requiring monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing and tachycardia.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: elevated lithium levels, potential toxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy, consider backup method.
  • Carbamazepine: may decrease metronidazole levels.
  • Rifampin: may lower metronidazole concentrations.

Frequently Asked Questions

Metronidazol Noridem, containing metronidazole, is prescribed for anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amoebic dysentery, and Clostridioides difficile infection, as determined by a qualified healthcare professional.

Metronidazole is reduced inside anaerobic microorganisms, producing reactive nitro radicals that bind to DNA and other cellular components, disrupting DNA synthesis and leading to microbial cell death.

The dosage of Metronidazol Noridem is individualized by the prescriber based on the specific infection, patient age, weight, renal and hepatic function, and local treatment guidelines.

Safety data are limited; the product should be used in pregnancy only if the potential benefit justifies the risk, and breastfeeding mothers should consult their physician before use.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Metronidazol Noridem offers the same spectrum of activity as other metronidazole products, but its intravenous formulation allows rapid systemic delivery, which can be advantageous in severe infections requiring immediate therapeutic levels.

Store at ambient temperature, preferably below 25 °C, in the original packaging. Protect from excessive light and moisture to maintain product stability.

Metronidazol Noridem is given by intravenous infusion under the supervision of a healthcare professional, following the dosing instructions provided by the prescribing clinician.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, liver toxicity, and neutropenia. Patients should be monitored for these signs and seek immediate medical attention if they occur.

Patients with known hypersensitivity to metronidazole or other nitroimidazoles, those with severe hepatic impairment, and individuals who cannot safely discontinue alcohol consumption should avoid using Metronidazol Noridem.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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