Product image of Metronidazol Normon (Metronidazole) supplied by GNH India

Metronidazol Normon

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Normon (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Normon, is a nitroimidazole antibiotic presented as an oral dosage form for oral use. It treats infections caused by anaerobic bacteria and certain protozoa in adults and children when prescribed, and is indicated for a range of bacterial and protozoal infections and is part of standard treatment guidelines.

GNH India supplies Metronidazol Normon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance across multiple markets.

Manufacturer / TM Owner

Laboratorios Normon, S.A.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and susceptible protozoa.

  • Bacterial vaginosis: eliminates the anaerobic bacteria responsible for the condition, restoring normal vaginal flora.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Amoebiasis: clears intestinal Entamoeba histolytica infection, reducing dysentery and liver abscess risk.
  • Giardiasis: treats Giardia lamblia infection, alleviating diarrhea and malabsorption.
  • Anaerobic bacterial infections: controls intra‑abdominal, skin and bone infections caused by susceptible anaerobes.

How It Works

  • Metronidazole enters susceptible microorganisms by passive diffusion. Inside anaerobic cells, the nitro group is reduced by ferredoxin‑type proteins, generating reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis and disrupt essential metabolic enzymes, leading to cell death. The selective activation in low‑oxygen environments provides targeted antimicrobial activity against anaerobes and certain protozoa. Because aerobic cells lack the necessary reduction pathways, metronidazole remains largely inactive in them, minimizing host toxicity.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Diarrhea

Serious or Rare Side Effects

  • Seizures
  • Peripheral neuropathy
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

Before using Metronidazol Normon, consider the following precautions.

  • Pregnancy: Category B; use only when the benefit outweighs potential risk.
  • Alcohol: Avoid concurrent alcohol consumption due to a disulfiram‑like reaction.
  • Renal impairment: Assess renal function and adjust dose if necessary.
  • Hepatic disease: Use with caution; monitor liver enzymes.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Metronidazol Normon can interact with several medicines; review them with a healthcare professional.

Major Interactions (Avoid)

  • Alcohol: may cause severe nausea, vomiting and flushing.
  • Warfarin: potentiates anticoagulant effect, increasing INR and bleeding risk.
  • Lithium: may raise lithium serum levels, leading to toxicity.
  • Cimetidine: can increase metronidazole plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Phenobarbital: may reduce metronidazole efficacy by increasing metabolism.
  • Carbamazepine: may lower plasma levels, decreasing therapeutic effect.
  • Oral contraceptives: may reduce hormonal efficacy; consider alternative contraception.

Frequently Asked Questions

Metronidazol Normon contains metronidazole, which is prescribed to treat infections caused by anaerobic bacteria and certain protozoa. Common clinical uses include bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, and a variety of intra‑abdominal, skin or bone infections where anaerobic organisms are identified.

Metronidazole is taken up by susceptible microorganisms and, under low‑oxygen conditions, its nitro group is reduced to reactive radicals. These radicals damage DNA and other essential macromolecules, inhibiting nucleic acid synthesis and leading to cell death. The drug is therefore selective for anaerobic bacteria and protozoa.

The exact dose of Metronidazol Normon is set by the prescribing clinician based on the type and severity of the infection, the patient’s age, weight, renal and hepatic function, and any concomitant medications. Patients should follow the prescriber’s instructions and never adjust the dose on their own.

Metronidazole is classified as Pregnancy Category B, indicating that animal studies have not shown risk and there are no well‑controlled studies in pregnant women. It may be used when the potential benefit justifies the potential risk. Breastfeeding mothers should discuss use with their healthcare provider, as small amounts can pass into milk.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metronidazol Normon (metronidazole) is the most widely used nitroimidazole, offering a broad spectrum against anaerobes and protozoa. Alternatives such as tinidazole have a longer half‑life and may require fewer doses, but metronidazole remains the first‑line choice for many infections due to extensive clinical experience, lower cost and well‑established dosing guidelines.

Store Metronidazol Normon at room temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, excessive heat and direct sunlight. Do not store in the bathroom or near a kitchen sink where humidity is high.

Metronidazol Normon is administered orally. It may be taken with or without food, although taking it with meals can reduce gastrointestinal upset for some patients. The tablet should be swallowed whole with a full glass of water unless otherwise directed by the prescriber.

Serious adverse reactions, although rare, include seizures, peripheral neuropathy that may be irreversible, and severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience unexplained seizures, numbness, tingling, or widespread rash.

Metronidazol Normon should be avoided in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles. Caution is also advised for patients with severe hepatic impairment, and it is contraindicated in the first trimester of pregnancy unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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