Product image of Metronidazol Orifarm (Metronidazole) supplied by GNH India

Metronidazol Orifarm

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Orifarm (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Orifarm, is a nitroimidazole antibiotic presented as an oral tablet for systemic use. It treats anaerobic bacterial infections and certain protozoal diseases in adults and children as prescribed.

GNH India supplies Metronidazol Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Metronidazol Orifarm is a nitroimidazole antibiotic used to manage infections caused by anaerobic bacteria and susceptible protozoa.

  • Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic overgrowth.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Anaerobic bacterial infections (intra‑abdominal, skin, bone): provides bactericidal activity against mixed anaerobes.
  • Amoebic dysentery (Entamoeba histolytica): clears intestinal trophozoites and cysts.
  • Clostridioides difficile infection (adjunct): reduces toxin‑producing bacterial load when used with standard therapy.

How It Works

  • Metronidazole is taken up by anaerobic microorganisms and reduced by intracellular redox proteins to reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to irreversible cell death of susceptible bacteria and protozoa.

Side Effects

Metronidazol Orifarm may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional dull or throbbing pain.
  • Diarrhea: loose stools that may be self‑limiting.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: serious skin and mucous membrane disorder.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Blood dyscrasias: neutropenia or agranulocytosis.

Precautions & Warnings

Before prescribing Metronidazol Orifarm, clinicians should consider several safety aspects.

  • Liver function assessment: monitor hepatic enzymes in patients with liver disease.
  • Alcohol avoidance: advise patients to abstain from alcohol to prevent disulfiram‑like reactions.
  • Pregnancy caution: use only if benefits outweigh potential risks, as safety data are limited.
  • Renal impairment: adjust dosing in severe kidney dysfunction.
  • Neurologic disorders: use cautiously in patients with seizure disorders or CNS disease.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazol Orifarm can interact with several medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium serum concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may reduce phenytoin levels, requiring dose adjustment.
  • Cimetidine: can increase metronidazole plasma concentrations.
  • Carbamazepine: may lower metronidazole levels, potentially reducing effectiveness.

Frequently Asked Questions

Metronidazol Orifarm is prescribed for infections caused by anaerobic bacteria and certain protozoa, including bacterial vaginosis, trichomoniasis, intra‑abdominal or skin anaerobic infections, amoebic dysentery, and as an adjunct in Clostridioides difficile infection when combined with standard therapy.

Metronidazole enters susceptible microorganisms and is reduced by their anaerobic metabolic pathways to form nitro radicals. These reactive species damage DNA and inhibit nucleic acid synthesis, ultimately causing cell death of the targeted bacteria or protozoa.

The specific dose and duration are determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal or hepatic function. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for metronidazole in pregnancy are limited, and the drug is generally used only when the potential benefit justifies any possible risk. It is excreted in breast milk, so breastfeeding mothers should discuss alternatives or precautions with their doctor.

To request Metronidazol Orifarm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metronidazole is a nitroimidazole that offers rapid bactericidal activity against a broad range of anaerobes and certain protozoa, often preferred for its oral formulation and good tissue penetration. Alternatives such as clindamycin or beta‑lactam/beta‑lactamase inhibitor combinations may be used, but metronidazole remains a first‑line choice for many anaerobic conditions due to its efficacy and cost‑effectiveness.

Metronidazol Orifarm should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency.

The medication is taken orally, usually with food or a full glass of water to reduce gastrointestinal irritation. The exact dosing schedule—such as once, twice, or three times daily—depends on the prescriber’s instructions for the specific infection being treated.

Serious adverse events, although rare, include seizures, peripheral neuropathy, severe allergic reactions (including anaphylaxis), Stevens‑Johnson syndrome, liver toxicity, and blood dyscrasias such as neutropenia. Patients should seek immediate medical attention if they experience neurological symptoms, rash, or signs of liver dysfunction.

Metronidazol Orifarm is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for individuals with severe hepatic impairment, a history of seizures, or those who cannot abstain from alcohol during therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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