Product image of Metronidazol Orifarm (Metronidazole) supplied by GNH India

Metronidazol Orifarm

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Orifarm (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Orifarm, is a nitroimidazole antibiotic presented as an oral tablet for systemic use. It treats anaerobic bacterial infections and certain protozoal infections in adults and children as prescribed.

GNH India supplies Metronidazol Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Metronidazole is used to manage infections caused by anaerobic bacteria and susceptible protozoa.

  • Bacterial vaginosis: eradicates the anaerobic bacteria responsible, relieving discharge and odor.
  • Trichomoniasis: eliminates Trichomonas vaginalis, curing infection and preventing recurrence.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites, treating intestinal and extra‑intestinal disease.
  • Anaerobic bacterial infections: targets a broad range of anaerobes in intra‑abdominal, pelvic, skin and soft‑tissue infections.
  • Clostridioides difficile infection: reduces toxin‑producing bacteria, aiding resolution of mild to moderate disease.

How It Works

  • Metronidazole is reduced by electron‑transport proteins in anaerobic organisms, forming reactive nitro radicals. These metabolites bind to DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to cell death of susceptible bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools that usually resolve after therapy.
  • Abdominal pain: cramp‑like discomfort in the abdomen.
  • Headache: mild to moderate headache during treatment.
  • Loss of appetite: reduced desire to eat.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate medical attention.
  • Peripheral neuropathy: tingling or numbness in extremities, potentially persistent.
  • Severe allergic reactions: anaphylaxis, swelling, or rash.
  • Stevens‑Johnson syndrome: severe skin blistering and detachment.
  • Pseudomembranous colitis: Clostridioides difficile overgrowth causing severe diarrhea.
  • Hepatotoxicity: elevated liver enzymes or liver injury.

Precautions & Warnings

Before prescribing Metronidazol Orifarm, clinicians should consider several safety factors.

  • Renal or hepatic impairment: adjust therapy and monitor function.
  • Alcohol consumption: avoid alcohol to prevent disulfiram‑like reactions.
  • Allergic history: assess for prior hypersensitivity to nitroimidazoles.
  • Pregnancy and breastfeeding: use only if benefits outweigh potential risks.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Metronidazol Orifarm can affect, or be affected by, other medicines.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, vomiting, and tachycardia.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: can raise lithium serum levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may reduce metronidazole concentrations, lowering efficacy.
  • Oral contraceptives: may decrease hormonal effectiveness, consider backup contraception.

Frequently Asked Questions

Metronidazol Orifarm contains metronidazole, which is prescribed for bacterial vaginosis, trichomoniasis, amoebiasis, a variety of anaerobic bacterial infections, and mild to moderate Clostridioides difficile infection. The drug targets organisms that thrive in low‑oxygen environments, helping to clear the infection and relieve associated symptoms.

Metronidazole is taken up by anaerobic bacteria and protozoa, where intracellular reduction converts its nitro group into reactive radicals. These radicals bind to DNA, causing strand breaks and inhibiting nucleic acid synthesis, which ultimately leads to microbial cell death while sparing most aerobic cells.

The specific dose of Metronidazol Orifarm is determined by the prescribing clinician based on the infection being treated, patient age, weight, renal and hepatic function, and other clinical factors. Healthcare providers set the appropriate regimen and duration for each individual case.

Safety data for metronidazole in pregnancy are limited, and the product does not have a definitive pregnancy category. It should be used only when the potential benefit justifies any possible risk to the fetus. Breastfeeding mothers should consult their healthcare professional, as the drug can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazol Orifarm is comparable to other metronidazole products in efficacy and spectrum of activity. Alternative nitroimidazoles such as tinidazole have longer half‑lives, which may allow less frequent dosing, but metronidazole remains the most widely used agent due to its extensive clinical experience, broad indication list, and established safety profile.

Metronidazol Orifarm should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Metronidazol Orifarm is taken orally, usually with food or a full glass of water to reduce gastrointestinal irritation. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious adverse events, though rare, include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, pseudomembranous colitis, and hepatotoxicity. Patients should seek immediate medical attention if they experience neurological symptoms, severe skin reactions, or signs of liver dysfunction.

Metronidazol Orifarm is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. It should also be avoided in patients with severe hepatic impairment or those who are actively consuming alcohol due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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