Product image of Metronidazol Polpharma (Metronidazole) supplied by GNH India

Metronidazol Polpharma

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Polpharma (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Polpharma, is a nitroimidazole antibiotic presented as a vaginal formulation for local use. It treats bacterial vaginosis, trichomoniasis and other anaerobic vaginal infections in women. The medication is indicated for adult female patients and is administered directly to the affected area.

GNH India supplies Metronidazol Polpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU quality standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and protozoa in the vaginal tract.

  • Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic bacteria.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Other anaerobic vaginal infections: treats less common anaerobic pathogens, reducing inflammation and discharge.

How It Works

  • Metronidazole is taken up by anaerobic microorganisms and reduced to reactive nitro radicals. These radicals interact with DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to bacterial and protozoal cell death without affecting aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Vaginal irritation: local burning or itching.
  • Headache: mild to moderate headache.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Stevens‑Johnson syndrome: severe skin reaction with blistering.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Anaphylaxis: life‑threatening allergic reaction with airway compromise.

Precautions & Warnings

Before prescribing Metronidazol Polpharma, consider the following precautions.

  • Pregnancy: Use only if clearly needed; safety not established.
  • Breastfeeding: Caution; drug may be excreted in milk.
  • Liver disease: Adjust use; drug is metabolized hepatically.
  • Alcohol consumption: Avoid; may cause a disulfiram‑like reaction.
  • Store below 25°C: keep in original pack, protect from moisture.

Avoid Interactions

Metronidazol Polpharma can interact with several medicines; review patient medication lists.

Major Interactions (Avoid)

  • Alcohol: causes severe flushing, nausea, tachycardia.
  • Warfarin: may increase anticoagulant effect, raising bleeding risk.
  • Lithium: can raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Phenytoin: may reduce metronidazole effectiveness.
  • Oral contraceptives: may reduce efficacy; advise backup contraception.

Frequently Asked Questions

Metronidazol Polpharma contains metronidazole and is prescribed to treat bacterial vaginosis, trichomoniasis and other anaerobic infections of the vagina. It works locally to eliminate the microorganisms responsible for these conditions, helping to restore normal vaginal flora and relieve symptoms such as discharge, odor and irritation.

Metronidazole enters anaerobic bacteria and protozoa and is reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, leading to cell death. The drug selectively targets organisms that thrive in low‑oxygen environments, sparing most aerobic cells.

The dosage of Metronidazol Polpharma is determined by the prescribing clinician based on the specific infection, severity and patient characteristics. Typical regimens vary, and the prescriber will provide detailed instructions on the amount, frequency and duration of therapy.

Safety data for metronidazole in pregnancy are limited, and the product should be used only when clearly needed. It is excreted in breast milk, so caution is advised for nursing mothers. The prescriber should weigh potential benefits against possible risks before initiating therapy.

To order, submit an enquiry on the Metronidazol Polpharma product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Metronidazole is a first‑line nitroimidazole antibiotic widely recommended for bacterial vaginosis because of its proven efficacy against anaerobic organisms. Alternatives such as clindamycin or tinidazole may be used, but metronidazole offers a well‑established safety profile and is often preferred for its oral and vaginal formulations.

Store Metronidazol Polpharma below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiration date. No special refrigeration is required for this vaginal formulation.

Metronidazol Polpharma is applied directly to the vagina, typically as a cream, gel or suppository, according to the prescriber’s instructions. The patient should follow the recommended duration of treatment and avoid sexual intercourse or tampon use if advised, to ensure optimal therapeutic effect.

Serious adverse events, although rare, include seizures, severe skin reactions such as Stevens‑Johnson syndrome, peripheral neuropathy and anaphylaxis. Patients should seek immediate medical attention if they experience neurological symptoms, widespread rash, swelling, difficulty breathing or any signs of an allergic reaction.

Metronidazol Polpharma should be avoided in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe liver impairment, those who consume alcohol heavily, and pregnant or breastfeeding women unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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