Product image of Metronidazol Ratiopharm (Metronidazole) supplied by GNH India

Metronidazol Ratiopharm

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Ratiopharm (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Ratiopharm, is a Nitroimidazole antibiotic presented as an oral tablet for oral use. It treats infections caused by anaerobic bacteria and certain protozoa, and is commonly prescribed for bacterial vaginosis, trichomoniasis, amoebiasis, and other anaerobic infections. It is indicated for adult patients and is available in dosage forms meeting European pharmacopeia standards.

GNH India supplies Metronidazol Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with quality‑assurance processes.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Bacterial vaginosis: reduces symptoms and eradicates the causative anaerobic bacteria.
  • Trichomoniasis: eliminates Trichomonas vaginalis and resolves genital inflammation.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites in intestinal disease.
  • Anaerobic bacterial infections: clears infections such as intra‑abdominal abscesses, pelvic inflammatory disease and bacterial peritonitis.

How It Works

  • Metronidazole enters anaerobic microorganisms and is reduced by ferredoxin proteins, generating reactive nitro radicals. These radicals cause DNA strand breakage, inhibit nucleic acid synthesis, and lead to cell death. The selective activation in low‑oxygen environments spares most aerobic host cells while targeting anaerobic bacteria and susceptible protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: persistent metallic sensation in the mouth.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools during therapy.

Serious or Rare Side Effects

  • Seizures: convulsive episodes requiring immediate medical attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: serious skin and mucous membrane disorder.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Blood dyscrasias: neutropenia, thrombocytopenia, or anemia.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: adjust dose in severe impairment.
  • Avoid alcohol: may cause a disulfiram‑like reaction.
  • Monitor for allergic reactions: discontinue if severe rash or anaphylaxis occurs.
  • Use with caution in pregnancy: risk unknown, weigh benefits against potential fetal exposure.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metronidazole can interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Alcohol: may produce severe flushing, tachycardia, and nausea.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: elevated lithium levels, potential toxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy, consider backup method.
  • Carbamazepine: may lower metronidazole concentrations, monitor therapeutic response.

Frequently Asked Questions

Metronidazol Ratiopharm contains metronidazole, which is prescribed for bacterial vaginosis, trichomoniasis, amoebiasis and a range of anaerobic bacterial infections such as intra‑abdominal or pelvic infections. The drug targets organisms that thrive in low‑oxygen environments.

Metronidazole is taken up by anaerobic microbes and reduced by their cellular proteins, forming reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis and ultimately cause cell death, selectively affecting anaerobic bacteria and certain protozoa while sparing most human cells.

The specific dose and treatment duration are determined by the prescribing clinician based on the infection type, severity, patient weight, renal function and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of metronidazole in pregnancy is not fully established; it is generally avoided in the first trimester and used only when the benefits outweigh potential risks. Breastfeeding mothers should consult their healthcare provider, as small amounts may be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metronidazole is a nitroimidazole, offering broad activity against anaerobic bacteria and protozoa, whereas alternatives such as tinidazole or ornidazole have similar mechanisms but differ in dosing frequency and side‑effect profiles. Choice of therapy depends on infection type, resistance patterns and patient tolerance.

Store the tablets at room temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Do not refrigerate or freeze the product, and keep it out of reach of children.

Metronidazol Ratiopharm is taken orally with a full glass of water. It may be taken with or without food, but taking it with meals can reduce gastrointestinal upset. The tablet should be swallowed whole and not chewed or crushed unless instructed by a healthcare professional.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, liver toxicity and blood dyscrasias like neutropenia. Patients should seek immediate medical attention if they experience neurological symptoms, rash, jaundice or unexplained bleeding.

Individuals with a known hypersensitivity to metronidazole or other nitroimidazoles should avoid the drug. Patients with severe hepatic impairment, those taking disulfiram, or those with a history of seizures should discuss alternatives with their clinician before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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