Product image of Metronidazol Stada (Metronidazole) supplied by GNH India

Metronidazol Stada

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Stada (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Stada, is a nitroimidazole antibiotic presented as an oral dosage form for oral use. It treats anaerobic bacterial and protozoal infections in adults and adolescents. It is indicated for conditions such as bacterial vaginosis, trichomoniasis, amoebiasis, and various anaerobic infections. The drug is formulated for systemic absorption and is widely used in both outpatient and inpatient settings.

GNH India supplies Metronidazol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and susceptible protozoa.

  • Bacterial vaginosis: eradicates Gardnerella vaginalis and restores normal vaginal flora.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Amoebiasis: clears intestinal Entamoeba histolytica infection, reducing dysentery and tissue invasion.
  • Intra‑abdominal anaerobic infections: controls mixed anaerobic bacterial populations, aiding resolution of abscesses.
  • Skin and soft‑tissue infections: manages anaerobic bacteria in cellulitis, abscesses and diabetic foot infections.
  • Clostridioides difficile infection (adjunct): reduces toxin‑producing bacterial load when used with standard therapy.

How It Works

  • Metronidazole diffuses into susceptible microorganisms and is reduced by ferredoxin‑type proteins under low‑oxygen conditions. This reduction generates reactive nitro radicals that cause DNA strand breakage, inhibit nucleic acid synthesis, and disrupt protein synthesis, ultimately leading to cell death. The selective activation in anaerobic environments accounts for its activity against anaerobic bacteria and certain protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset often occurring early in therapy.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools that resolve after discontinuation.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Peripheral neuropathy: numbness or tingling in extremities that may be irreversible.
  • Seizures: rare convulsive episodes requiring immediate medical attention.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Hepatotoxicity: elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Metronidazol Stada, consider several safety aspects.

  • Pregnancy: use only if clearly needed; fetal risk not fully established.
  • Alcohol interaction: avoid alcohol to prevent a disulfiram‑like reaction.
  • Liver disease: monitor hepatic function and adjust dose if necessary.
  • Renal impairment: use with caution in severe renal failure.
  • Concomitant medications: review for potential interactions, especially anticoagulants.
  • Store at ambient temperature: keep below 25 °C, in the original pack, and protect from moisture.

Avoid Interactions

Metronidazol Stada can interact with several drug classes.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: can increase anticoagulant effect, raising bleeding risk.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Phenytoin: may reduce metronidazole levels, decreasing efficacy.
  • Oral contraceptives: may reduce effectiveness; advise additional contraceptive methods.

Frequently Asked Questions

Metronidazol Stada contains metronidazole, which is prescribed to treat a range of anaerobic bacterial and protozoal infections. Common clinical uses include bacterial vaginosis, trichomoniasis, amoebiasis, intra‑abdominal infections, skin and soft‑tissue infections, and as an adjunct in Clostridioides difficile infection therapy.

Metronidazole enters susceptible microorganisms and is reduced in low‑oxygen environments. The reduction creates reactive nitro radicals that damage DNA, inhibit nucleic acid synthesis, and disrupt protein production, leading to microbial cell death. This selective activation explains its effectiveness against anaerobic bacteria and certain protozoa.

The dosage of Metronidazol Stada is determined by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and treatment guidelines. Patients should follow the exact regimen provided by their healthcare professional and not adjust the dose on their own.

Safety data for metronidazole during pregnancy are limited, and the drug should only be used when clearly needed and after risk‑benefit assessment by a qualified practitioner. Limited information is available for breastfeeding; however, small amounts may be excreted in milk, so a healthcare provider should be consulted before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Metronidazol Stada. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazol Stada offers a broad spectrum against anaerobic bacteria and protozoa, often providing a single‑agent option where combination therapy might be required with other antibiotics. Compared with macrolides or quinolones, metronidazole has a distinct mechanism targeting low‑oxygen organisms, making it the preferred choice for conditions like bacterial vaginosis and trichomoniasis.

Metronidazol Stada should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Metronidazol Stada is administered orally. The tablet (or other oral dosage form) should be swallowed with a full glass of water, preferably with food to reduce gastrointestinal upset, unless the prescribing information advises otherwise.

Serious adverse reactions can include peripheral neuropathy, which may be irreversible, seizures, severe allergic responses such as anaphylaxis, and hepatotoxicity manifested by elevated liver enzymes or jaundice. Patients should seek immediate medical attention if they experience numbness, convulsions, rash with swelling, or signs of liver dysfunction.

Metronidazol Stada is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic impairment, known central nervous system disorders, or those who are currently consuming alcohol due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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