Product image of Metronidazol Vioser (Metronidazole) supplied by GNH India

Metronidazol Vioser

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Vioser (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Vioser, is a nitroimidazole antibiotic presented as an intravenous formulation for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in adults and children as prescribed.

GNH India supplies Metronidazol Vioser as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Vioser S.A.

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Indications & Clinical Uses

Metronidazol Vioser is indicated for a range of anaerobic and protozoal infections. It targets the underlying microorganisms to eradicate infection and improve clinical outcomes.

  • Anaerobic bacterial infections: effective against mixed anaerobic infections, reducing bacterial load.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms.
  • Intra‑abdominal infections: controls polymicrobial intra‑abdominal sepsis.
  • Pelvic inflammatory disease: treats anaerobic components of PID.
  • Clostridioides difficile‑associated diarrhea: reduces toxin‑producing bacteria in the colon.

How It Works

  • Metronidazole is reduced by anaerobic organisms to reactive nitro radicals that interact with DNA, causing strand breakage and inhibition of nucleic acid synthesis. This DNA damage leads to cell death in susceptible bacteria and protozoa, while aerobic cells are largely unaffected due to limited drug activation.

Side Effects

Metronidazol Vioser may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Diarrhea

Serious or Rare Side Effects

  • Seizures
  • Peripheral neuropathy
  • Severe allergic reactions (anaphylaxis)
  • Stevens‑Johnson syndrome

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for potential complications.

  • Renal impairment: adjust dose as recommended by prescriber.
  • Hepatic dysfunction: monitor liver function tests.
  • Alcohol consumption: avoid during therapy due to disulfiram‑like reaction.
  • Pregnancy: Category B; use only if benefit outweighs risk.
  • Duplicate therapy: avoid concurrent use of other metronidazole‑containing products.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Metronidazol Vioser can interact with several medicines; some require avoidance, others close monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause severe nausea and vomiting (disulfiram‑like reaction).
  • Warfarin: may potentiate anticoagulant effect, increasing INR.
  • Lithium: may raise lithium levels, increasing toxicity risk.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Phenobarbital: may reduce metronidazole levels.
  • Oral contraceptives: may reduce efficacy; advise additional contraception.

Frequently Asked Questions

Metronidazol Vioser is an intravenous formulation of metronidazole used to treat anaerobic bacterial infections and certain protozoal infections such as bacterial vaginosis, trichomoniasis, intra‑abdominal infections, pelvic inflammatory disease, and Clostridioides difficile‑associated diarrhea.

Metronidazole is taken up by anaerobic microorganisms and reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, leading to cell death in susceptible bacteria and protozoa while sparing aerobic cells.

The dosage and duration of Metronidazol Vioser are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here.

Metronidazol Vioser is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy only if the potential benefit justifies the risk. Caution is advised during breastfeeding, and the prescriber should evaluate infant exposure.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. The team then replies with pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Metronidazol Vioser shares the same class mechanism as tinidazole and ornidazole but differs in pharmacokinetics. Metronidazole has a shorter half‑life, requiring more frequent dosing, while tinidazole offers a longer half‑life and may be dosed less often. Choice depends on infection type, patient tolerance, and prescriber preference.

Store Metronidazol Vioser at ambient temperature, below 25 °C, in its original packaging. Protect the solution from light, moisture, and extreme temperatures. Do not freeze. Follow standard aseptic handling procedures for intravenous products.

Metronidazol Vioser is administered intravenously by a qualified healthcare professional. It is typically diluted in compatible IV fluids and infused over a prescribed period, according to the prescriber's instructions and institutional protocols.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, and rare skin conditions like Stevens‑Johnson syndrome. Patients should be monitored for neurological symptoms, rash, or signs of hypersensitivity, and therapy should be discontinued if severe reactions occur.

Metronidazol Vioser is contraindicated in patients with known hypersensitivity to metronidazole or other nitroimidazoles. It should also be avoided in individuals with a history of severe reactions to the drug, and caution is required in patients with significant hepatic or renal impairment unless dose adjustments are made.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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