Product image of Metronidazol Vioser (Metronidazole) supplied by GNH India

Metronidazol Vioser

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Vioser (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Vioser, is a nitroimidazole antibiotic presented as an intravenous solution for injection use. It treats a range of anaerobic bacterial and protozoal infections in adult and paediatric patients as prescribed by a qualified health professional.

GNH India supplies Metronidazol Vioser as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vioser S.A.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Anaerobic bacterial infections: eradicates susceptible anaerobes and reduces infection severity.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating over‑growth of anaerobic bacteria.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Amoebic dysentery: destroys Entamoeba histolytica trophozoites, controlling intestinal disease.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile, aiding clinical recovery.

How It Works

  • Metronidazole enters susceptible anaerobic microorganisms and is reduced by intracellular electron‑transport proteins to reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to cell death in anaerobic bacteria and protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: mild to moderate headache episodes.
  • Diarrhoea: loose stools during therapy.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate medical attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane reaction.
  • Hepatic toxicity: elevated liver enzymes or jaundice.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Metronidazole requires careful monitoring in specific clinical situations.

  • Renal function assessment: adjust therapy in patients with impaired kidney function.
  • Hepatic monitoring: use cautiously in liver disease and watch for elevated enzymes.
  • Alcohol avoidance: advise patients to abstain from alcohol during and 48 hours after treatment.
  • Allergic reaction vigilance: discontinue if signs of hypersensitivity appear.
  • Pregnancy and lactation: prescribe only when benefits outweigh potential risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Disulfiram‑like reaction with alcohol: severe flushing, tachycardia, hypotension.
  • Warfarin: increased anticoagulant effect, monitor INR closely.
  • Lithium: elevated lithium levels, risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Phenytoin: may reduce metronidazole levels, monitor therapeutic response.

Frequently Asked Questions

Metronidazol Vioser, containing metronidazole, is prescribed for anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amoebic dysentery, and Clostridioides difficile infection. It is administered intravenously under medical supervision to target susceptible microorganisms in these conditions.

Metronidazole penetrates anaerobic cells and is reduced to nitro radicals that damage DNA and inhibit nucleic acid synthesis. This disruption leads to bacterial and protozoal cell death while sparing aerobic organisms, making it effective for a range of anaerobic and protozoal infections.

The specific dose and duration of Metronidazol Vioser are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. Only a qualified health professional should set the dosing regimen.

Metronidazol Vioser is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It should be used during pregnancy only if the potential benefit justifies any potential risk. Caution is also advised while breastfeeding, and the prescriber should evaluate the risk‑benefit balance.

To request Metronidazol Vioser, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazol Vioser belongs to the nitroimidazole class, which is uniquely effective against obligate anaerobes and certain protozoa. Compared with beta‑lactam antibiotics, it offers a broader spectrum for anaerobic organisms and does not rely on beta‑lactamase stability, making it a preferred option for mixed anaerobic infections.

Metronidazol Vioser should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and potency.

Metronidazol Vioser is supplied as an intravenous solution for injection. It is administered by a qualified healthcare professional through a sterile IV line, following aseptic technique and the dosing instructions provided by the prescriber.

Serious adverse reactions include seizures, peripheral neuropathy, severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, hepatic toxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin reactions, liver function changes, and blood count abnormalities during therapy.

Metronidazol Vioser is contraindicated in patients with known hypersensitivity to metronidazole or other nitroimidazole compounds. It should also be avoided in individuals with severe hepatic impairment or those who cannot abstain from alcohol during and shortly after treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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