Product image of Metronidazol Ziaja (Metronidazole) supplied by GNH India

Metronidazol Ziaja

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Ziaja (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Ziaja, is a nitroimidazole presented as a topical formulation for skin use. It is employed to manage rosacea, acne vulgaris, and other bacterial skin infections in appropriate patients.
GNH India supplies Metronidazol Ziaja as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ziaja Ltd. Zakład Produkcji Leków Sp. Z O.O.

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Indications & Clinical Uses

Metronidazole is used in dermatology to target anaerobic bacteria and inflammatory lesions.

  • Rosacea: reduces papules, pustules and erythema associated with the condition.
  • Acne vulgaris: decreases inflammatory lesions and bacterial colonisation of the skin.
  • Bacterial skin infections: treats localized infections caused by susceptible anaerobic organisms.

How It Works

  • Metronidazole penetrates microbial cells and undergoes enzymatic reduction of its nitro group under anaerobic conditions. The resulting reactive intermediates generate free radicals that damage DNA, proteins and other essential biomolecules, leading to irreversible cell injury and death of anaerobic bacteria and protozoa.

Side Effects

Metronidazole topical therapy may cause local and systemic reactions.

Common Side Effects

  • Skin irritation: mild redness or itching at the application site.
  • Dryness: transient scaling or flaking of the treated area.
  • Burning sensation: brief warmth or tingling after application.
  • Pruritus: occasional itching unrelated to infection.
  • Contact dermatitis: mild allergic response in sensitive individuals.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Stevens‑Johnson syndrome: rare severe skin blistering.
  • Methemoglobinemia: bluish discoloration of skin or lips.
  • Systemic toxicity: nausea, headache, or dizziness if absorbed in large amounts.
  • Persistent ulceration: non‑healing skin breakdown at the site.

Precautions & Warnings

When using Metronidazol Ziaja, follow these safety measures.

  • Avoid application on broken or severely inflamed skin: may increase systemic absorption.
  • Do not use with other topical antibiotics unless directed: risk of irritation.
  • Limit exposure to eyes and mucous membranes: can cause irritation.
  • Monitor for signs of allergic reaction: discontinue if severe symptoms develop.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazol Ziaja may interact with certain systemic agents and topical products.

Major Interactions (Avoid)

  • Alcohol consumption: risk of disulfiram‑like reaction with systemic absorption.
  • Concurrent systemic metronidazole: may increase systemic exposure and toxicity.

Moderate Interactions (Monitor Closely)

  • Other topical antiseptics (e.g., chlorhexidine): potential for increased skin irritation.
  • Warfarin: systemic absorption could potentiate anticoagulant effect; monitor INR if used long‑term.
  • Lithium: possible increase in lithium levels with extensive absorption; monitor serum lithium.

Frequently Asked Questions

Metronidazol Ziaja is a topical formulation of metronidazole indicated for the treatment of rosacea, acne vulgaris, and localized bacterial skin infections caused by susceptible anaerobic organisms. It helps reduce inflammation, lesions, and bacterial load on the skin.

Metronidazole penetrates the skin’s microbial cells and, under anaerobic conditions, its nitro group is reduced to reactive intermediates. These free radicals damage DNA and essential proteins of anaerobic bacteria and protozoa, leading to cell death and resolution of infection and inflammation.

The specific dosing regimen for Metronidazol Ziaja is determined by the prescribing healthcare professional based on the indication, severity of the condition, and patient factors. Patients should follow the instructions provided by their prescriber and the product label.

Safety data for topical metronidazole in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits and risks before prescribing to pregnant or nursing individuals. If used, it should be applied to the smallest area necessary and for the shortest duration required.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Metronidazol Ziaja belongs to the nitroimidazole class, offering anti‑anaerobic and anti‑inflammatory effects. Compared with antibiotics like clindamycin or azelaic acid, metronidazole provides a distinct mechanism targeting anaerobic bacteria and may be preferred when those agents are ineffective or contraindicated.

Store the product below 25 °C in its original packaging, protecting it from moisture, heat and direct sunlight. Ensure the container is tightly closed to maintain product stability and prevent contamination.

Apply a thin layer of the cream or gel to the affected skin area once or twice daily, as directed by the prescriber. Wash hands before and after application, and avoid contact with eyes, mouth and open wounds.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and methemoglobinemia. If any signs of systemic toxicity, widespread rash, blistering, or difficulty breathing occur, discontinue use immediately and seek medical attention.

Individuals with known hypersensitivity to metronidazole or any component of the formulation should avoid using the product. It is also contraindicated on extensively damaged or ulcerated skin, and caution is advised in patients with a history of severe allergic reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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