Product image of Metronidazole Βιοσερ (Metronidazole) supplied by GNH India

Metronidazole Βιοσερ

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Βιοσερ (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Βιοσερ, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal diseases in adults and children as prescribed.

GNH India supplies Metronidazole Βιοσερ as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vioser S.A.

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Bacterial vaginosis: eradicates the anaerobic flora responsible for the condition.
  • Trichomoniasis: eliminates the protozoan parasite Trichomonas vaginalis.
  • Anaerobic intra‑abdominal infections: controls mixed anaerobic bacterial populations in the abdominal cavity.
  • Clostridioides difficile‑associated colitis: suppresses toxin‑producing C. difficile bacteria.
  • Amebic liver abscess: destroys Entamoeba histolytica organisms in hepatic tissue.

How It Works

  • Metronidazole is reduced within anaerobic microorganisms, converting its nitro group to reactive intermediates that bind to DNA. This causes strand breakage and inhibits nucleic acid synthesis, leading to cell death of susceptible bacteria and protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: persistent metallic sensation in the mouth.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools during therapy.

Serious or Rare Side Effects

  • Seizures: neurological events requiring immediate attention.
  • Peripheral neuropathy: tingling or numbness of extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: serious skin eruption.
  • Hepatic toxicity: elevated liver enzymes or jaundice.
  • Neutropenia: reduced white blood cell count.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: adjust use in severe impairment.
  • Monitor hepatic function: exercise caution in liver disease.
  • Avoid alcohol: risk of disulfiram‑like reaction.
  • Pregnancy category B: prescribe only when benefit outweighs risk.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several medicines; awareness helps prevent complications.

Major Interactions (Avoid)

  • Alcohol: may cause severe nausea and vomiting.
  • Warfarin: increased anticoagulant effect, monitor INR closely.
  • Lithium: elevated lithium levels, monitor for toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma concentrations.
  • Phenytoin: may reduce metronidazole effectiveness.

Frequently Asked Questions

Metronidazole Βιοσερ is prescribed for bacterial vaginosis, trichomoniasis, intra‑abdominal and pelvic anaerobic infections, Clostridioides difficile‑associated colitis, and amebic liver abscesses. It targets anaerobic bacteria and certain protozoa, helping to eliminate the infectious organisms responsible for these conditions.

The drug is taken up by anaerobic microorganisms and reduced to reactive nitro radicals. These radicals bind to DNA, causing strand breakage and blocking nucleic acid synthesis, which leads to cell death of susceptible bacteria and protozoa while sparing aerobic cells.

The specific dose and duration are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. Healthcare professionals should follow local guidelines and individual patient needs.

Metronidazole is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy only if the potential benefit justifies the risk. Caution is advised during breastfeeding; consult a healthcare provider.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Metronidazole is uniquely effective against obligate anaerobes and certain protozoa, offering a broad spectrum for anaerobic infections. Alternatives such as clindamycin or beta‑lactam/beta‑lactamase inhibitor combinations may be used, but metronidazole often provides superior activity against anaerobic Gram‑negative rods and protozoal pathogens.

Store at ambient temperature: keep the vial in its original packaging, protect from moisture and direct light, and avoid freezing. Ensure the container is tightly sealed when not in use to maintain product stability.

Metronidazole Βιοσερ is given by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate and dilution are determined by the prescriber and nursing staff according to the specific clinical protocol.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatic toxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and blood count alterations during treatment.

Metronidazole is contraindicated in patients with a known hypersensitivity to the drug or other nitroimidazoles. Caution is also required for individuals with severe hepatic impairment, those receiving disulfiram, and patients with a history of seizures or neuropathy unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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