Product image of Metronidazole Accord Healthcare (Metronidazole) supplied by GNH India

Metronidazole Accord Healthcare

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Accord Healthcare (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Accord Healthcare, is a nitroimidazole antibiotic presented as an oral tablet for oral use. It treats a range of anaerobic bacterial and protozoal infections in adult and pediatric patients as prescribed by a healthcare professional.

GNH India supplies Metronidazole Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa. It is indicated for the following conditions:

  • Bacterial vaginosis: restores normal vaginal flora and relieves discharge.
  • Trichomoniasis: eliminates Trichomonas vaginalis and resolves symptoms.
  • Amoebiasis: eradicates Entamoeba histolytica causing intestinal disease.
  • Giardiasis: clears Giardia lamblia infection and reduces diarrhea.
  • Anaerobic bacterial infections: targets mixed‑flora infections such as intra‑abdominal or pelvic abscesses.
  • Clostridioides difficile infection: reduces toxin‑producing bacteria and improves colitis symptoms.

How It Works

  • Metronidazole enters susceptible microbial cells and undergoes reduction of its nitro group. The reduced metabolite binds to DNA, causing strand breakage and inhibition of nucleic acid synthesis, which leads to cell death in anaerobic bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: cramping or discomfort.
  • Headache: mild to moderate headache.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: serious skin eruption.
  • Pseudomembranous colitis: Clostridioides difficile overgrowth.
  • Hepatic toxicity: elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Metronidazole, clinicians should consider several safety factors.

  • Pregnancy: safety not established; use only if benefits outweigh risks.
  • Breastfeeding: drug may be excreted in milk; caution advised.
  • Alcohol: avoid concurrent intake to prevent disulfiram‑like reaction.
  • Renal impairment: dose adjustment may be required in severe dysfunction.
  • Hepatic impairment: monitor liver function and adjust dose if needed.
  • Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: heightened lithium toxicity.
  • Cimetidine: elevated metronidazole plasma levels.
  • Phenobarbital: reduced metronidazole effectiveness.

Moderate Interactions (Monitor Closely)

  • Erythromycin: may increase metronidazole concentrations.
  • Phenytoin: may lower metronidazole levels.
  • Theophylline: potential increase in theophylline toxicity.

Frequently Asked Questions

Metronidazole Accord Healthcare is prescribed for infections caused by anaerobic bacteria and certain protozoa, including bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, anaerobic intra‑abdominal infections, and Clostridioides difficile‑associated colitis. The specific indication depends on the clinical diagnosis made by a qualified healthcare professional.

Metronidazole penetrates susceptible microbial cells and is reduced at the nitro group. The reduced form binds to DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to cell death in anaerobic bacteria and protozoa.

The dosage of Metronidazole Accord Healthcare is determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal or hepatic function. Patients should follow the exact regimen provided on the prescription label.

Safety data for metronidazole in pregnancy are limited, and it is generally avoided unless the potential benefit justifies the risk. The drug can be excreted in breast milk, so caution is advised for nursing mothers, and a healthcare provider should evaluate the risk‑benefit ratio.

To request Metronidazole Accord Healthcare, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms and certain protozoa, offering a narrow spectrum that reduces impact on normal flora compared with broad‑spectrum agents like clindamycin or carbapenems. Its oral formulation and good tissue penetration make it a first‑line choice for many anaerobic infections, though resistance patterns and patient factors may guide alternative selection.

Metronidazole Accord Healthcare tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

The medication is taken orally, usually with food or a full glass of water to lessen gastrointestinal irritation. Tablets should be swallowed whole and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious adverse events, though rare, include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, pseudomembranous colitis, and hepatic toxicity. Patients should seek immediate medical attention if they experience neurological symptoms, severe skin reactions, or signs of liver injury.

Metronidazole should be avoided in individuals with a known hypersensitivity to the drug or other nitroimidazole compounds. Caution is also required for patients with severe hepatic or renal impairment, those taking disulfiram, and individuals who consume alcohol during therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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