Product image of Metronidazole Aurobindo (Metronidazole) supplied by GNH India

Metronidazole Aurobindo

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Aurobindo (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Aurobindo, is a nitroimidazole antibiotic presented as an oral tablet for systemic use. It treats a range of anaerobic bacterial and protozoal infections in adults and children as prescribed by a healthcare professional.

GNH India supplies Metronidazole Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Metronidazole is a nitroimidazole agent used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Bacterial vaginosis: eradicates the anaerobic bacteria responsible for vaginal discharge and odor.
  • Trichomoniasis: eliminates Trichomonas vaginalis infection in the genitourinary tract.
  • Amoebiasis: clears intestinal Entamoeba histolytica infection and associated dysentery.
  • Giardiasis: treats Giardia lamblia infection causing diarrhoea.
  • Anaerobic bacterial infections: combats mixed‑flora infections in the abdomen, skin and oral cavity.
  • Clostridioides difficile infection: reduces toxin‑producing C. difficile in the colon.

How It Works

  • Metronidazole is reduced by electron‑transport proteins in anaerobic organisms, generating reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis, ultimately leading to microbial cell death without affecting aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional dull or throbbing headache.
  • Diarrhoea: loose stools that resolve after therapy.

Serious or Rare Side Effects

  • Peripheral neuropathy: tingling or numbness in extremities.
  • Seizures: rare occurrence of convulsive episodes.
  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.

Precautions & Warnings

Before prescribing Metronidazole, clinicians should consider the following safety measures.

  • Liver function: assess hepatic status as the drug is metabolised hepatically.
  • Alcohol consumption: advise patients to avoid alcohol due to disulfiram‑like reaction.
  • Neurological history: monitor for signs of neuropathy, especially with prolonged use.
  • Pregnancy and lactation: evaluate risk‑benefit ratio; use only if clearly needed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Metronidazole can alter the activity of several concomitant medicines.

Major Interactions (Avoid)

  • Disulfiram: concurrent use may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: increased anticoagulant effect leading to heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • Lithium: may raise serum lithium levels; monitor renal function and lithium concentrations.
  • Cimetidine: can increase metronidazole plasma concentrations; observe for enhanced toxicity.
  • Phenytoin: may reduce phenytoin levels; adjust dosage if therapeutic monitoring indicates.

Frequently Asked Questions

Metronidazole Aurobindo is prescribed for bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, various anaerobic bacterial infections and Clostridioides difficile infection. It targets organisms that thrive in low‑oxygen environments, helping to clear the infection when used as directed by a healthcare professional.

Metronidazole is taken up by anaerobic bacteria and protozoa, where intracellular reduction of its nitro group creates reactive radicals. These radicals damage microbial DNA and inhibit nucleic acid synthesis, leading to cell death while sparing most aerobic cells.

The specific dose and duration of Metronidazole Aurobindo are determined by the prescribing clinician based on the infection type, severity, patient age, weight and renal or hepatic function. Patients should follow the exact regimen provided on the prescription label.

Safety of Metronidazole in pregnancy or lactation depends on the trimester and clinical necessity. It is generally avoided in the first trimester unless benefits outweigh risks, and caution is advised while breastfeeding. Physicians should evaluate each case individually.

To request Metronidazole Aurobindo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Metronidazole is a first‑line nitroimidazole with broad activity against anaerobic bacteria and protozoa, offering oral convenience and a well‑characterised safety profile. Alternatives such as tinidazole have similar efficacy but differ in dosing frequency and side‑effect spectrum, making Metronidazole a common choice for many indications.

Metronidazole Aurobindo tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Metronidazole Aurobindo is supplied as oral tablets that are swallowed whole with a glass of water. It may be taken with or without food, although taking it with meals can reduce gastrointestinal upset in some patients.

Serious adverse reactions to Metronidazole include peripheral neuropathy, seizures and severe allergic responses such as anaphylaxis. Patients should seek immediate medical attention if they experience numbness, tingling, convulsions, rash, swelling or breathing difficulties.

Metronidazole Aurobindo is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles. It should also be avoided in patients with severe hepatic impairment or those who are concurrently using disulfiram, due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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