Product image of Metronidazole B. Braun (Metronidazole) supplied by GNH India

Metronidazole B. Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole B. Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazole B. Braun, is a nitroimidazole antibiotic presented as an intravenous solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in adult patients.

GNH India supplies Metronidazole B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic indicated for a range of anaerobic and protozoal infections.

  • Anaerobic bacterial infections: eradicates mixed anaerobic flora in deep‑tissue infections.
  • Intra‑abdominal infections: treats peritonitis, abscesses and postoperative intra‑abdominal sepsis.
  • Pelvic inflammatory disease: eliminates anaerobic organisms contributing to PID.
  • Bacterial vaginosis: restores normal vaginal flora by targeting Gardnerella and other anaerobes.
  • Clostridioides difficile‑associated diarrhea: reduces toxin‑producing C. difficile in the colon.

How It Works

  • Metronidazole is taken up by anaerobic microorganisms and reduced by their ferredoxin proteins to reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to irreversible cell death of susceptible bacteria and protozoa.

Side Effects

Metronidazole may cause a variety of adverse reactions.

Common Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Dizziness
  • Diarrhea
  • Abdominal discomfort

Serious or Rare Side Effects

  • Seizures
  • Peripheral neuropathy
  • Severe allergic reactions (anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatic toxicity
  • Neutropenia or agranulocytosis

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Renal impairment: adjust therapy based on renal function.
  • Hepatic dysfunction: monitor liver enzymes during treatment.
  • Alcohol consumption: avoid due to risk of a disulfiram‑like reaction.
  • Pregnancy: use only when the potential benefit justifies the potential risk to the fetus.
  • Concurrent use with disulfiram or alcohol‑containing products: contraindicated.
  • Store at controlled room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Metronidazole can interact with several medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause a severe disulfiram‑like reaction.
  • Warfarin: may potentiate anticoagulant effect and increase INR.
  • Lithium: may raise serum lithium concentrations.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma levels.
  • Phenobarbital: may reduce metronidazole concentrations.
  • Erythromycin: may increase risk of neurotoxicity.

Frequently Asked Questions

Metronidazole B. Braun is indicated for anaerobic bacterial infections, intra‑abdominal infections, pelvic inflammatory disease, bacterial vaginosis, Clostridioides difficile‑associated diarrhea, and amebic liver abscesses. It targets organisms that thrive in low‑oxygen environments and is used in adult patients when a parenteral route is required.

Metronidazole enters anaerobic bacteria and protozoa and is reduced by intracellular electron‑transfer proteins to form nitro radicals. These reactive species damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, resulting in irreversible cell death of the targeted microorganisms.

The dose and duration of Metronidazole B. Braun are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and local treatment guidelines. No fixed dosing can be provided without a medical prescription.

The safety of Metronidazole B. Braun in pregnancy has not been definitively established; it should be used only when the potential benefit outweighs any possible risk to the fetus. Limited data suggest it passes into breast milk, so caution is advised and breastfeeding decisions should be made with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazole is unique among anaerobic antibiotics because it is selectively activated within anaerobic cells, offering rapid bactericidal activity. Compared with clindamycin or beta‑lactam/beta‑lactamase inhibitor combinations, metronidazole often provides a narrower spectrum focused on anaerobes, which can reduce collateral impact on normal flora but may require combination therapy for mixed infections.

Metronidazole B. Braun should be stored at controlled room temperature, typically below 25 °C, in its original packaging. The container should be kept away from direct sunlight, moisture, and extreme temperature fluctuations to maintain product stability.

Metronidazole B. Braun is supplied as an intravenous solution and is administered directly into a vein by a qualified healthcare professional. The infusion rate and concentration are set by the prescriber according to the clinical situation and patient-specific factors.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, hepatic toxicity, and hematologic abnormalities like neutropenia. Patients should be monitored for neurological symptoms, skin reactions, and liver function during therapy.

Metronidazole B. Braun is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazoles, and in individuals who have consumed alcohol or are taking disulfiram due to the risk of a severe disulfiram‑like reaction. Caution is also advised for patients with severe hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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