Product image of Metronidazole B. Braun (Metronidazole) supplied by GNH India

Metronidazole B. Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole B. Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazole B. Braun, is a nitroimidazole antibiotic presented as an injection for intravenous use. It treats anaerobic bacterial infections and certain protozoal diseases in adult and pediatric patients.

GNH India supplies Metronidazole B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Metronidazole is employed to manage infections caused by anaerobic bacteria and selected protozoa.

  • Anaerobic bacterial infections: effective against mixed anaerobic flora, reducing infection severity.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Amebic liver abscess: targets Entamoeba histolytica, aiding resolution of hepatic lesions.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile, helping control colitis.

How It Works

  • Metronidazole is reduced inside anaerobic microorganisms by ferredoxin‑type proteins, forming nitro radical anions that damage DNA and inhibit nucleic acid synthesis, ultimately causing cell death. This selective activation in low‑oxygen environments provides targeted antimicrobial activity while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional mild headache.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: light‑headed feeling.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Neutropenia: low white‑blood‑cell count.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Metronidazole requires careful monitoring in specific patient populations and clinical situations.

  • Renal function assessment: adjust use in severe renal impairment.
  • Hepatic function monitoring: watch for liver enzyme elevations.
  • Alcohol avoidance: risk of disulfiram‑like reaction.
  • Pregnancy safety: Category B, use only if benefits outweigh risks.
  • CNS disorders caution: may exacerbate seizures.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing and tachycardia.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: heightened neurotoxicity risk.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: may reduce metronidazole levels.
  • Cimetidine: can increase metronidazole plasma concentration.
  • Oral contraceptives: may reduce hormonal efficacy, consider backup contraception.

Frequently Asked Questions

Metronidazole B. Braun is indicated for the treatment of anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amebic liver abscess, and Clostridioides difficile infection. It is administered intravenously to target organisms that thrive in low‑oxygen environments, providing an effective antimicrobial option in hospital and clinical settings.

Metronidazole is taken up by anaerobic microorganisms and reduced by intracellular electron‑transfer proteins. This reduction creates reactive nitro radical anions that damage DNA, inhibit nucleic acid synthesis, and ultimately lead to cell death. The drug’s activation is selective for low‑oxygen organisms, sparing most aerobic cells.

The dosage of Metronidazole B. Braun is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal and hepatic function, and other clinical factors. Healthcare professionals set the appropriate dose and infusion rate for each individual case.

Metronidazole is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no well‑controlled human studies. It may be used during pregnancy when the potential benefit justifies the potential risk. Limited data are available for breastfeeding, so clinicians should weigh benefits against possible exposure to the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details—including any cold‑chain requirements—and required import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic bacteria and certain protozoa, offering rapid bactericidal activity. Compared with broad‑spectrum agents like clindamycin or beta‑lactams, metronidazole provides a narrower spectrum focused on anaerobes, often with fewer drug‑interaction concerns. Choice of therapy depends on infection type, susceptibility patterns, and patient factors.

Metronidazole B. Braun should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If the product reaches room temperature, it may be used within the time frame specified by the manufacturer, but refrigeration should be restored promptly.

Metronidazole B. Braun is administered intravenously by a healthcare professional. The drug is supplied as a sterile solution for injection and is typically infused over a prescribed period, often 30‑60 minutes, depending on the clinical protocol. Proper aseptic technique and infusion equipment are required to ensure safe delivery.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as Stevens‑Johnson syndrome, and hepatotoxicity. Patients should be monitored for neurological symptoms, skin changes, and liver function abnormalities. Prompt medical attention is required if any severe or unexpected reactions occur during treatment.

Metronidazole B. Braun is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. Caution is also advised for individuals with severe hepatic impairment, those receiving disulfiram, and patients with a history of seizures unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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