Product image of Metronidazole Braun (Metronidazole) supplied by GNH India

Metronidazole Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Braun, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in adult patients.

GNH India supplies Metronidazole Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU pharmacopeial standards and is manufactured under GMP conditions, ensuring consistent quality for acute care settings. It is distributed through GNH India's regulated supply chain, meeting the requirements of health authorities in multiple jurisdictions.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Metronidazole is employed to treat infections caused by anaerobic bacteria and susceptible protozoa.
  • Anaerobic bacterial infections: eradicates mixed anaerobic flora in intra‑abdominal and soft‑tissue infections.
  • Intra‑abdominal infections: reduces infection severity following perforated viscus or postoperative contamination.
  • Pelvic inflammatory disease: targets anaerobic organisms contributing to PID, aiding clinical resolution.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating Gardnerella and other anaerobes.
  • Trichomoniasis: effective against Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Clostridioides difficile infection: used as part of therapy to suppress toxin‑producing anaerobes.

How It Works

  • Metronidazole enters susceptible anaerobic bacteria and protozoa by passive diffusion. Inside the cell, reduction of its nitro group by ferredoxin‑type proteins generates reactive nitro radicals that interact with DNA, causing strand breakage and inhibition of nucleic acid synthesis, ultimately leading to cell death. The drug is selectively activated in low‑oxygen environments, sparing aerobic host cells and providing a therapeutic window.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Diarrhea
  • Abdominal pain
  • Dizziness

Serious or Rare Side Effects

  • Seizures
  • Peripheral neuropathy
  • Severe allergic reactions (anaphylaxis, skin rash)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatic toxicity (elevated transaminases, hepatitis)
  • Neutropenia or agranulocytosis

Precautions & Warnings

Before initiating Metronidazole Braun, clinicians should consider several safety precautions.

  • Assess renal function: adjust dosing or avoid use in severe renal impairment.
  • Monitor hepatic enzymes: watch for signs of liver injury during therapy.
  • Avoid in known hypersensitivity: discontinue immediately if allergic reaction occurs.
  • Use with caution in pregnancy: risk to fetus is unclear; weigh benefits against potential harm.
  • Limit duration of therapy: prolonged use may increase resistance and toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metronidazole can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing, nausea, and tachycardia.
  • Warfarin: increased anticoagulant effect, raising risk of bleeding.
  • Lithium: concurrent use can raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Phenobarbital: may reduce metronidazole levels, decreasing effectiveness.
  • Erythromycin: can raise metronidazole concentrations, requiring monitoring.

Frequently Asked Questions

Metronidazole Braun is an intravenous formulation of metronidazole used to treat a range of anaerobic bacterial infections and certain protozoal diseases, including intra‑abdominal infections, pelvic inflammatory disease, bacterial vaginosis, trichomoniasis, and Clostridioides difficile infection. It is administered in hospital or clinical settings where rapid systemic exposure is required.

Metronidazole is taken up by anaerobic microorganisms and reduced by intracellular electron‑transfer proteins. This reduction creates reactive nitro radicals that bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, which ultimately leads to cell death. The activation occurs preferentially in low‑oxygen environments, sparing most aerobic human cells.

The specific dose and duration of Metronidazole Braun are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and local treatment guidelines. Healthcare professionals select the appropriate regimen and adjust it as needed for individual patient factors.

Safety data for Metronidazole Braun during pregnancy and lactation are limited. The drug is classified as Category ? in many regions, indicating that potential benefits must be weighed against possible risks to the fetus or infant. Clinicians should consider alternative therapies when possible and discuss any concerns with the patient.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if required), and necessary import documentation.

Metronidazole is a nitroimidazole that offers rapid bactericidal activity against obligate anaerobes and certain protozoa, often with a narrower spectrum than broad‑spectrum agents such as carbapenems. It is generally well‑tolerated, inexpensive, and available in IV form, making it a first‑line choice for many intra‑abdominal and gynecologic anaerobic infections.

Metronidazole Braun should be stored at 2‑8 °C in a refrigerator, protected from light. The vial must not be frozen or shaken vigorously. Before use, inspect the solution for particulate matter or discoloration and discard if any abnormalities are observed.

Metronidazole Braun is given by intravenous infusion under the supervision of qualified healthcare personnel. The infusion rate and dilution volume are determined by the prescriber and pharmacy staff, typically using compatible IV fluids. Administration should follow aseptic technique and institutional protocols for IV drug delivery.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, hepatic toxicity, and hematologic abnormalities like neutropenia. Patients should be monitored for neurological symptoms, skin reactions, and liver function changes, especially during prolonged therapy.

Metronidazole Braun is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic or renal impairment, those receiving disulfiram, and patients for whom alternative therapies are more appropriate due to pregnancy or lactation concerns.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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