Product image of Metronidazole Fresenius (Metronidazole) supplied by GNH India

Metronidazole Fresenius

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Fresenius (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Fresenius, is a nitroimidazole presented as an injection for intravenous use. It treats anaerobic bacterial infections and certain protozoal diseases in adults and children as prescribed.

GNH India supplies Metronidazole Fresenius as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and susceptible protozoa.

  • Anaerobic bacterial infections: effective against mixed anaerobic infections, reducing bacterial load and clinical symptoms.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating over‑growth of anaerobic organisms.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Amebic liver abscess: eliminates Entamoeba histolytica in hepatic tissue, aiding resolution of the abscess.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile, helping to control colitis.

How It Works

  • Metronidazole is reduced within susceptible anaerobic microorganisms to generate nitro radical anions. These reactive species interact with DNA, causing strand breakage and loss of helical structure, which inhibits nucleic acid synthesis and leads to cell death. The selective reduction occurs under low‑oxygen conditions, sparing aerobic host cells.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient alteration of taste perception.
  • Headache: occasional mild to moderate headache.
  • Diarrhea: loose stools that may be self‑limiting.

Serious or Rare Side Effects

  • Seizures: rare neurologic events, especially with high plasma levels.
  • Peripheral neuropathy: tingling or numbness in extremities with prolonged use.
  • Severe allergic reactions: anaphylaxis or angioedema requiring immediate medical attention.

Precautions & Warnings

Metronidazole requires careful consideration of patient‑specific factors before use.

  • Pregnancy: safety not established; use only if benefits outweigh potential risks.
  • Renal impairment: dose may need adjustment; monitor renal function regularly.
  • Hepatic impairment: caution advised; monitor liver enzymes during therapy.
  • Alcohol consumption: avoid; concurrent intake can cause a disulfiram‑like reaction.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may produce severe disulfiram‑like reactions.
  • Warfarin: can enhance anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce hormonal efficacy, consider backup contraception.
  • Cimetidine: can increase metronidazole plasma levels, monitor for toxicity.

Frequently Asked Questions

Metronidazole Fresenius is indicated for a range of anaerobic bacterial infections and certain protozoal diseases, including bacterial vaginosis, trichomoniasis, amebic liver abscess, and Clostridioides difficile‑associated colitis. It is administered intravenously under the direction of a qualified prescriber.

Inside susceptible anaerobic organisms, Metronidazole is reduced to nitro radical anions. These reactive molecules damage DNA and inhibit nucleic acid synthesis, leading to bacterial or protozoal cell death while sparing aerobic host cells.

The dosage and duration of Metronidazole Fresenius are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here.

Safety data for Metronidazole in pregnancy are limited, and the drug is classified as category unknown. It should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult a healthcare professional before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms and certain protozoa, offering a broad spectrum against Gram‑negative and Gram‑positive anaerobes. Alternatives such as clindamycin or beta‑lactam/beta‑lactamase inhibitor combinations may be used, but Metronidazole often provides a more focused, cost‑effective option for infections where anaerobes predominate.

Metronidazole Fresenius should be stored at 2‑8 °C in a refrigerator. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. Do not use if the product appears discolored or particulate.

The product is supplied as a sterile injection for intravenous infusion. Administration is performed by qualified healthcare personnel, typically diluted in an appropriate compatible solution and infused over the period recommended by the prescriber, based on the infection being treated.

Serious adverse events, though rare, include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, and hepatic dysfunction. Patients should be monitored for neurological symptoms, skin reactions, and liver function abnormalities, especially during prolonged therapy.

Metronidazole is contraindicated in patients with a known hypersensitivity to the drug or other nitroimidazoles. Caution is also advised for individuals with severe hepatic impairment, those taking disulfiram, and patients with a history of seizures or neuropathy until evaluated by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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