Product image of Metronidazole Mercury Pharmaceuticals (Metronidazole) supplied by GNH India

Metronidazole Mercury Pharmaceuticals

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Mercury Pharmaceuticals (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Mercury Pharmaceuticals, is a nitroimidazole presented as a topical formulation for skin use. It is employed to manage certain bacterial and protozoal skin conditions, particularly in adult patients with rosacea, acne vulgaris, or other dermatologic infections.

GNH India supplies Metronidazole Mercury Pharmaceuticals as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Mercury Pharmaceuticals Ltd.

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antimicrobial used topically for several dermatologic conditions.

  • Rosacea: reduces inflammatory lesions and erythema, improving skin appearance.
  • Acne vulgaris: decreases bacterial colonisation and inflammation, leading to fewer pimples.
  • Dermatologic infections: treats susceptible bacterial or protozoal skin infections, promoting lesion resolution.

How It Works

  • Metronidazole is taken up by anaerobic or microaerophilic cells and undergoes reduction to generate reactive nitro radicals. These radicals interact with DNA, causing strand breaks and inhibiting nucleic acid synthesis, which ultimately leads to microbial cell death. The selective activation in low‑oxygen environments provides targeted antimicrobial activity while sparing most aerobic host cells.

Side Effects

Topical metronidazole may cause local and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Skin irritation: redness, itching or burning at the application site.
  • Dryness: localized skin dryness or flaking.
  • Pruritus: mild itching.
  • Contact dermatitis: allergic skin reaction.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Stevens‑Johnson syndrome: rare severe skin blistering.
  • Neurotoxicity: rare peripheral neuropathy or dizziness.

Precautions & Warnings

When using topical metronidazole, consider the following safety measures.

  • Pregnancy: safety not established; use only if benefits outweigh risks.
  • Breastfeeding: may be excreted in milk; consult a healthcare professional.
  • Liver disease: monitor because the drug is metabolised hepatically.
  • Alcohol consumption: avoid excessive intake as it may increase side effects.
  • Sun exposure: may increase skin sensitivity; use sunscreen.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing and nausea.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may reduce metronidazole levels, decreasing efficacy.
  • Cimetidine: may increase metronidazole plasma concentration.
  • Oral contraceptives: may have reduced effectiveness; consider alternative contraception.

Frequently Asked Questions

Metronidazole Mercury Pharmaceuticals is a topical nitroimidazole indicated for the treatment of rosacea, acne vulgaris, and other dermatologic infections caused by susceptible bacteria or protozoa. It helps reduce inflammation, lesions, and bacterial colonisation on the skin when applied as directed by a healthcare professional.

Metronidazole enters anaerobic or microaerophilic cells and is reduced to reactive nitro radicals. These radicals damage microbial DNA and inhibit nucleic acid synthesis, leading to cell death. The drug’s selective activation in low‑oxygen environments provides targeted antimicrobial activity against the organisms that cause the skin conditions it treats.

The exact dose, frequency, and duration of treatment are determined by the prescribing clinician based on the specific condition, severity, patient age, and other individual factors. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Safety data for topical metronidazole in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss the treatment with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Metronidazole differs from many topical antibiotics because it targets anaerobic organisms and protozoa through DNA damage rather than inhibiting cell‑wall synthesis. It is especially effective for inflammatory lesions of rosacea, whereas agents like clindamycin primarily address acne‑related bacteria. Choice of therapy depends on the underlying pathogen, clinical presentation and physician preference.

Store the product below 25 °C in its original packaging, protecting it from moisture and direct light. Keep the container tightly closed when not in use. Do not freeze or expose the medication to extreme temperatures, as this could affect its stability and efficacy.

The medication is applied topically to the affected skin area, usually once or twice daily, as directed by a healthcare professional. Clean and gently pat the skin dry before applying a thin layer of the product. Avoid contact with eyes, mucous membranes, and broken skin unless specifically instructed.

Serious adverse reactions, although rare, include severe allergic responses such as swelling, hives, or difficulty breathing, and severe skin conditions like Stevens‑Johnson syndrome. Neurological symptoms such as peripheral neuropathy or dizziness may also occur. If any of these signs develop, discontinue use and seek immediate medical attention.

Patients with a known hypersensitivity to metronidazole or any component of the formulation should avoid its use. Individuals with severe liver impairment should use it only under close medical supervision. Pregnant or breastfeeding women should only use it if the prescriber determines that the benefits outweigh potential risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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