Product image of Metronidazole Noridem (Metronidazole) supplied by GNH India

Metronidazole Noridem

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Noridem (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Noridem, is a nitroimidazole antibiotic presented as an intravenous solution for intravenous use. It treats a range of anaerobic bacterial and protozoal infections in adult patients, including bacterial vaginosis, trichomoniasis, amoebiasis, intra‑abdominal infections, and pelvic inflammatory disease.

GNH India supplies Metronidazole Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring quality compliance with EU standards and reliable cold‑chain logistics where required through its global distribution network.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic that targets anaerobic bacteria and susceptible protozoa, making it useful for several infection types.

  • Anaerobic bacterial infections: effective treatment of intra‑abdominal, pelvic and other infections caused by anaerobic organisms.
  • Bacterial vaginosis: eradicates the bacterial flora responsible for the condition.
  • Trichomoniasis: eliminates Trichomonas vaginalis in affected patients.
  • Amoebiasis: clears intestinal and extra‑intestinal Entamoeba infections.
  • Intra‑abdominal infections: controls mixed aerobic‑anaerobic infections after surgery.
  • Pelvic inflammatory disease: reduces pathogenic anaerobes contributing to PID.

How It Works

  • Metronidazole enters susceptible anaerobic cells and is reduced by microbial redox proteins to reactive nitro radicals. These radicals interact with DNA, causing strand breakage and loss of helical structure, and also damage proteins and other macromolecules, ultimately leading to irreversible cell death of the pathogen.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: persistent metallic sensation in the mouth.
  • Headache: occasional mild to moderate headache.
  • Diarrhea: loose stools during therapy.

Serious or Rare Side Effects

  • Seizures: rare neurologic events, especially with high doses.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: anaphylaxis, rash, or angioedema.

Precautions & Warnings

Metronidazole requires careful use in specific patient populations and clinical situations.

  • Assess renal function: adjust therapy in severe impairment.
  • Monitor hepatic function: watch for signs of liver toxicity.
  • Avoid use in first trimester: limited safety data for early pregnancy.
  • Use with caution in CNS disorders: increased risk of seizures.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing and tachycardia.
  • Warfarin: increased anticoagulant effect, raising bleeding risk.
  • Lithium: heightened lithium toxicity due to reduced clearance.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma levels.
  • Phenytoin: may reduce metronidazole effectiveness.

Frequently Asked Questions

Metronidazole Noridem is indicated for the treatment of anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amoebiasis, intra‑abdominal infections, and pelvic inflammatory disease. It is prescribed by a qualified health professional based on the specific infection being treated.

Metronidazole is taken up by anaerobic microorganisms and reduced to reactive nitro radicals. These radicals damage DNA and essential proteins, leading to loss of cellular function and death of the pathogen, thereby clearing the infection.

The dosage and duration of Metronidazole Noridem are determined by the prescribing clinician according to the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here.

Safety data for metronidazole in pregnancy are limited, and the product is generally avoided in the first trimester. Use during later pregnancy or while breastfeeding should only occur if the potential benefit outweighs the potential risk, under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic bacteria and certain protozoa, offering a broad spectrum against these organisms. Alternatives such as clindamycin or beta‑lactam/beta‑lactamase inhibitor combinations may be used, but metronidazole often provides a more focused approach with a well‑characterized safety profile.

Store at ambient temperature: keep the vial in its original packaging, protect from light, and avoid exposure to moisture. Do not freeze the product. Follow any additional handling instructions provided by the supplier.

Metronidazole Noridem is supplied as an intravenous solution and is administered by slow infusion into a vein under the supervision of a qualified health professional. The infusion rate and duration are set by the prescriber based on the clinical scenario.

Serious risks include seizures, peripheral neuropathy, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for neurological symptoms, skin reactions, and signs of hypersensitivity, and therapy should be stopped immediately if these occur.

Metronidazole Noridem should be avoided in patients with known hypersensitivity to metronidazole or other nitroimidazoles, in those with severe hepatic impairment, and in early pregnancy unless the benefits clearly outweigh the risks. Caution is also advised for patients with a history of seizures or central nervous system disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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