Product image of Metronidazole Noridem (Metronidazole) supplied by GNH India

Metronidazole Noridem

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Noridem (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Noridem, is a nitroimidazole presented as an IV solution for intravenous use. It treats anaerobic bacterial and protozoal infections in adults and children as prescribed.

GNH India supplies Metronidazole Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Metronidazole Noridem is a nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic overgrowth.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Amoebic dysentery: clears Entamoeba histolytica infection in the intestine.
  • Clostridioides difficile infection: reduces toxin‑producing C. difficile, aiding resolution of colitis.
  • Anaerobic bacterial infections: targets a broad range of anaerobes in intra‑abdominal, pelvic and soft‑tissue infections.

How It Works

  • Metronidazole enters susceptible anaerobic cells and is reduced by ferredoxin proteins to generate nitro‑radical anions. These reactive intermediates damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to bacterial and protozoal cell death while sparing aerobic organisms.

Side Effects

Metronidazole Noridem may cause a range of adverse reactions, some of which are more frequent than others.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: mild to moderate headache.
  • Diarrhea: loose stools during treatment.
  • Skin rash: mild erythema or itching.
  • Dark urine: harmless discoloration due to metabolites.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Anaphylaxis: acute allergic reaction with respiratory compromise.

Precautions & Warnings

Before using Metronidazole Noridem, consider the following safety measures.

  • Renal impairment: adjust therapy if kidney function is reduced.
  • Hepatic disease: monitor liver function tests during treatment.
  • Alcohol consumption: avoid alcohol to prevent disulfiram‑like reaction.
  • Pregnancy: discuss risks with a healthcare professional; use only if clearly needed.
  • Lactation: assess benefit‑risk before breastfeeding.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metronidazole Noridem can interact with other medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Disulfiram: may cause severe flushing and hypotension.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: heightened lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma levels.
  • Phenytoin: may reduce phenytoin concentrations.
  • Alcoholic beverages: can intensify disulfiram‑like reaction.

Frequently Asked Questions

Metronidazole Noridem is indicated for anaerobic bacterial infections and certain protozoal diseases, including bacterial vaginosis, trichomoniasis, amoebic dysentery, Clostridioides difficile colitis, and other intra‑abdominal or soft‑tissue anaerobic infections as determined by a prescriber.

Metronidazole is taken up by anaerobic organisms and reduced to nitro‑radical anions. These reactive species damage DNA and inhibit nucleic acid synthesis, leading to cell death while sparing most aerobic cells.

The dosage and duration of Metronidazole Noridem are set by the prescribing clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and local treatment guidelines.

Safety in pregnancy and lactation is not fully established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic bacteria and protozoa, offering rapid bactericidal activity. Compared with broad‑spectrum agents like clindamycin, it has a narrower spectrum focused on anaerobes, often resulting in fewer disturbances to normal flora and a different side‑effect profile.

Metronidazole Noridem should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze the solution or shake it vigorously, and keep it in the original packaging until use.

Metronidazole Noridem is supplied as an intravenous solution and is administered by slow infusion into a vein, typically under the supervision of a healthcare professional in a hospital or clinical setting.

Serious risks include seizures, peripheral neuropathy, severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity, and anaphylaxis. Patients should be monitored for neurological symptoms, liver dysfunction, and any signs of allergic reaction during therapy.

Metronidazole Noridem is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles. Caution is also advised for patients with severe hepatic impairment, and it should be avoided in those with a history of severe allergic reactions to related compounds.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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