Product image of Metronidazole Polpharma (Metronidazole) supplied by GNH India

Metronidazole Polpharma

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Polpharma (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Polpharma, is a nitroimidazole antibiotic presented as an intravenous solution for intravenous use. It is indicated for the treatment of anaerobic bacterial infections and selected protozoal diseases in both adult and pediatric patients, administered under the direction of a qualified healthcare professional.

GNH India supplies Metronidazole Polpharma as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, clinics and procurement teams worldwide under strict quality‑assured conditions. The company adheres to EU GMP standards and offers reliable logistics for timely delivery.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic that targets anaerobic bacteria and certain protozoa.

  • Anaerobic bacterial infections: eliminates infection by killing susceptible anaerobic organisms.
  • Trichomoniasis: eradicates Trichomonas vaginalis causing vaginal infection.
  • Amoebiasis: treats intestinal infection caused by Entamoeba histolytica.
  • Bacterial vaginosis: restores normal vaginal flora by reducing overgrowth of anaerobes.
  • Clostridioides difficile infection: reduces toxin‑producing C. difficile in the colon.

How It Works

  • Metronidazole enters susceptible anaerobic microorganisms and is reduced by intracellular electron transport proteins to generate nitro radical anions. These reactive intermediates covalently bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, which leads to loss of cellular function and bacterial or protozoal cell death. The selective reduction occurs only in low‑oxygen environments, sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: mild headache.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Seizures: rare central nervous system events.
  • Hepatotoxicity: elevated liver enzymes or jaundice.

Precautions & Warnings

Before using Metronidazole Polpharma, consider the following precautions.

  • Pregnancy: use only if clearly needed, as safety data are limited.
  • Breastfeeding: evaluate risk, drug may be excreted in milk.
  • Liver disease: dose adjustment may be required in hepatic impairment.
  • Alcohol consumption: avoid during treatment and for 48 hours after, to prevent disulfiram‑like reaction.
  • Drug‑induced neutropenia: monitor blood counts in prolonged therapy.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Metronidazole can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Disulfiram: concurrent use can cause severe flushing, tachycardia, and hypotension.
  • Warfarin: may increase anticoagulant effect, raising bleeding risk.
  • Lithium: can raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Phenobarbital: may reduce metronidazole levels, decreasing effectiveness.
  • Alcohol: can cause a disulfiram‑like reaction; advise avoidance.

Frequently Asked Questions

Metronidazole Polpharma is used to treat infections caused by anaerobic bacteria and certain protozoa, including anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amoebiasis, and Clostridioides difficile infection. It is administered under medical supervision and is prescribed based on the specific diagnosis and patient needs.

Metronidazole is taken up by anaerobic microorganisms and reduced to reactive nitro radical anions. These anions bind to DNA and other critical macromolecules, causing strand breakage and inhibition of nucleic acid synthesis, which ultimately leads to cell death of the targeted bacteria or protozoa.

The dosage of Metronidazole Polpharma is determined by the prescribing clinician based on the infection being treated, patient weight, renal and hepatic function, and other clinical factors. Only a qualified healthcare professional can set the appropriate dose and treatment duration.

Safety data for Metronidazole in pregnancy are limited, so it should be used only when clearly needed and after risk‑benefit assessment by the prescriber. During breastfeeding, the drug can be excreted in milk; a healthcare professional should evaluate the potential risks before continuing therapy.

To order Metronidazole Polpharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms and certain protozoa, offering a broad spectrum against these pathogens. Compared with beta‑lactam antibiotics, it provides a different mechanism of action and is often preferred when resistance to other classes is a concern or when treating protozoal infections.

Metronidazole Polpharma should be stored below 25 °C, in its original packaging, protected from light and moisture. Maintaining these conditions helps preserve the stability and potency of the intravenous solution throughout its shelf life.

Metronidazole Polpharma is supplied as an intravenous solution and is administered by a qualified healthcare professional through a vein. The infusion rate and duration are determined by the prescribing clinician based on the indication and patient-specific factors.

Serious risks include severe allergic reactions (such as anaphylaxis), peripheral neuropathy, seizures, and hepatotoxicity. Patients should be monitored for signs of these reactions, and therapy should be discontinued immediately if any serious adverse event occurs.

Metronidazole Polpharma should be avoided in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic impairment, a history of seizures, or those taking medications that may interact dangerously, such as disulfiram.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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