Product image of Metronidazole Remedica (Metronidazole) supplied by GNH India

Metronidazole Remedica

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Remedica (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Remedica, is a nitroimidazole antibiotic presented as an oral tablet for oral use. It treats anaerobic bacterial and protozoal infections in adults and adolescents.

GNH India supplies Metronidazole Remedica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

Metronidazole is indicated for a range of anaerobic bacterial and protozoal infections.

  • Bacterial vaginosis: eradicates the pathogenic bacterial flora and restores normal vaginal microbiota.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Amoebic dysentery (Entamoeba histolytica): clears intestinal amoebae and resolves dysenteric symptoms.
  • Anaerobic bacterial infections (intra‑abdominal, pelvic, skin and soft‑tissue): provides bactericidal activity against susceptible anaerobes.
  • Clostridioides difficile infection (adjunct therapy): reduces toxin‑producing bacterial load when used with standard therapy.

How It Works

  • Metronidazole is taken up by anaerobic microorganisms and reduced by intracellular electron‑transport proteins to reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis and disrupt critical metabolic pathways, leading to irreversible cell death of the targeted bacteria or protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: mild to moderate headache.
  • Abdominal pain: cramping or discomfort in the abdomen.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Seizures: convulsions, especially with high plasma levels.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
  • Hepatic dysfunction: jaundice or elevated liver enzymes.
  • Pancytopenia: reduction in blood cell counts.
  • Disulfiram‑like reaction: flushing, tachycardia, and hypotension when alcohol is consumed.

Precautions & Warnings

Before prescribing Metronidazole, clinicians should consider several safety factors.

  • Renal function assessment: adjust use in severe renal impairment.
  • Hepatic monitoring: evaluate liver enzymes during prolonged therapy.
  • Alcohol avoidance: advise patients of a disulfiram‑like reaction.
  • Pregnancy risk evaluation: weigh potential benefits against unknown fetal risk.
  • Hypersensitivity check: discontinue if signs of severe allergy appear.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing, tachycardia and nausea.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium serum concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: reduces metronidazole levels, potentially decreasing efficacy.
  • Cimetidine: can increase metronidazole plasma concentrations.
  • Carbamazepine: may lower metronidazole exposure, requiring clinical monitoring.

Frequently Asked Questions

Metronidazole Remedica is a prescription‑only oral antibiotic used to treat infections caused by anaerobic bacteria and certain protozoa. Indications include bacterial vaginosis, trichomoniasis, amoebic dysentery, intra‑abdominal or pelvic anaerobic infections, skin and soft‑tissue infections, and as an adjunct in Clostridioides difficile infection.

Metronidazole enters susceptible anaerobic microorganisms and is reduced by their internal electron‑transport proteins to form nitro radicals. These reactive species damage DNA and inhibit nucleic acid synthesis, leading to irreversible cell death of the targeted bacteria or protozoa.

The specific dose and duration are determined by the prescribing clinician based on the infection type, severity, patient age, weight, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Metronidazole’s pregnancy category is listed as unknown, and safety data are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as the drug can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Metronidazole is a nitroimidazole, similar to tinidazole and ornidazole. Compared with tinidazole, metronidazole generally requires a longer treatment course but is more widely available and less expensive. Both share a similar spectrum against anaerobes and protozoa, though tinidazole may have a slightly lower incidence of certain gastrointestinal side effects.

Metronidazole Remedica tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiration date printed on the packaging.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with meals may reduce gastrointestinal upset. Patients should swallow the tablet whole and not crush or chew it unless specifically instructed by a healthcare professional.

Serious adverse reactions include seizures, peripheral neuropathy, severe allergic responses such as anaphylaxis or Stevens‑Johnson syndrome, hepatic dysfunction, and pancytopenia. Patients should seek immediate medical attention if they experience neurological symptoms, severe skin reactions, jaundice, or unexplained bleeding.

Metronidazole is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. Caution is advised for patients with severe hepatic or renal impairment, and it should be avoided in those who consume alcohol during therapy due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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