Product image of Metronidazole Sg-Pharm (Metronidazole) supplied by GNH India

Metronidazole Sg-Pharm

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Sg-Pharm (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Sg-Pharm, is a nitroimidazole antibiotic presented as an oral tablet for systemic use. It treats a range of anaerobic bacterial and protozoal infections in adults and children as prescribed by a healthcare professional.

GNH India supplies Metronidazole Sg-Pharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Substipharm

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa. It is effective in several clinical settings:

  • Bacterial vaginosis: eradicates the anaerobic bacteria responsible for the condition, relieving discharge and odor.
  • Trichomoniasis: eliminates Trichomonas vaginalis, curing infection and preventing transmission.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites, treating intestinal and extra‑intestinal disease.
  • Giardiasis: clears Giardia lamblia from the gastrointestinal tract, resolving diarrhea and malabsorption.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile, aiding recovery from colitis.
  • Anaerobic bacterial infections: targets a broad spectrum of anaerobes in intra‑abdominal, pelvic and skin‑soft‑tissue infections.

How It Works

  • Metronidazole enters susceptible anaerobic organisms and is reduced by intracellular redox proteins, generating reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to bacterial or protozoal cell death without affecting aerobic cells.

Side Effects

Metronidazole may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools that may be watery.
  • Headache: mild to moderate head discomfort.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reaction: hives, swelling, or anaphylaxis.

Precautions & Warnings

Before prescribing Metronidazole, consider the following safety measures:

  • Pregnancy: Category B – use only if the potential benefit justifies the potential risk to the fetus.
  • Liver function: monitor hepatic enzymes in patients with liver disease.
  • Alcohol consumption: avoid alcohol to prevent a disulfiram‑like reaction.
  • Renal impairment: adjust therapy in severe kidney dysfunction.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole can interact with several medicines; awareness of interaction severity helps guide monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: reduces phenytoin concentrations, possibly decreasing seizure control.
  • Cimetidine: can increase metronidazole plasma levels, enhancing side effects.
  • Oral contraceptives: may reduce hormonal efficacy, requiring additional contraceptive measures.

Frequently Asked Questions

Metronidazole Sg-Pharm is indicated for bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, Clostridioides difficile infection, and other anaerobic bacterial infections. It targets organisms that thrive in low‑oxygen environments, providing a broad spectrum of antiprotozoal and antibacterial activity when prescribed by a qualified clinician.

The drug is taken up by anaerobic bacteria and protozoa and undergoes intracellular reduction of its nitro group. This creates reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis, ultimately leading to cell death while sparing most aerobic cells.

The specific dose and treatment duration are determined by the prescribing healthcare professional based on the infection type, severity, patient age, weight, and renal or hepatic function. Patients should follow the prescriber’s instructions and the product labeling precisely.

Metronidazole is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are limited human data. It may be used during pregnancy only if the potential benefit outweighs any risk. Small amounts are excreted in breast milk; breastfeeding decisions should be made with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Metronidazole is the most widely used nitroimidazole, offering a broad spectrum against anaerobic bacteria and protozoa. Compared with alternatives such as tinidazole, it has a similar efficacy profile but a shorter half‑life, which may require more frequent dosing. Choice of agent depends on infection type, patient tolerance, and local resistance patterns.

Metronidazole Sg-Pharm tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain potency throughout its shelf life.

The medication is supplied as oral tablets and is taken by mouth with or without food, as directed by a healthcare professional. Swallow the tablet whole with water; do not crush or chew unless specifically instructed. Full course completion is essential for optimal therapeutic outcome.

Serious adverse events, though rare, include seizures, peripheral neuropathy, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience neurological symptoms, rash, or signs of an allergic response while on therapy.

Metronidazole is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. It should also be avoided in patients with severe hepatic impairment or in those who are actively consuming alcohol due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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