Product image of Metronidazole Svp Pharma (Metronidazole) supplied by GNH India

Metronidazole Svp Pharma

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Svp Pharma (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Svp Pharma, is a nitroimidazole antibiotic presented as an intravenous solution for intravenous use. It treats anaerobic bacterial infections, intra‑abdominal infections, pelvic inflammatory disease, bacterial vaginosis, trichomoniasis, and Clostridioides difficile colitis in adult patients.
GNH India supplies Metronidazole Svp Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Svp Pharma Ltd

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic that targets anaerobic bacteria and certain protozoa.

  • Anaerobic bacterial infections: eradicates anaerobic organisms to resolve infection.
  • Intra‑abdominal infections: controls mixed aerobic‑anaerobic infections within the abdominal cavity.
  • Pelvic inflammatory disease: eliminates anaerobic pathogens contributing to PID.
  • Bacterial vaginosis: restores normal vaginal flora by suppressing anaerobic overgrowth.
  • Trichomoniasis: kills Trichomonas vaginalis, the protozoan cause of the disease.
  • Clostridioides difficile colitis: reduces toxin‑producing C. difficile bacteria in the colon.

How It Works

  • Metronidazole is reduced by electron‑transport proteins of anaerobic microorganisms, converting its nitro group into reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and lead to cell death, selectively targeting anaerobic bacteria and susceptible protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional mild headache.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reaction (anaphylaxis): rapid onset of hives, swelling, or breathing difficulty.
  • Stevens‑Johnson syndrome: severe skin rash and mucosal involvement.
  • Liver toxicity: elevated liver enzymes or hepatitis.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Metronidazole should be used with careful clinical oversight.

  • Assess renal function: adjust therapy in patients with impaired kidney function.
  • Monitor hepatic function: watch for liver enzyme elevations during prolonged use.
  • Avoid alcohol: prevent disulfiram‑like reactions.
  • Use with caution in pregnancy: category B, discuss risks with obstetrician.
  • Use with caution in patients with CNS disorders: monitor for seizures or neuropathy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Metronidazole can interact with several medicines, requiring vigilance.

Major Interactions (Avoid)

  • Alcohol: may cause severe disulfiram‑like reaction.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may increase lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: reduces metronidazole plasma levels.
  • Cimetidine: may raise metronidazole concentrations.
  • Carbamazepine: may lower metronidazole exposure.

Frequently Asked Questions

Metronidazole Svp Pharma is an intravenous nitroimidazole antibiotic indicated for the treatment of anaerobic bacterial infections, intra‑abdominal infections, pelvic inflammatory disease, bacterial vaginosis, trichomoniasis, and Clostridioides difficile colitis. It is administered by healthcare professionals to target susceptible microorganisms in these conditions.

Metronidazole is taken up by anaerobic microorganisms and reduced by their electron‑transport proteins. This reduction creates reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis, leading to bacterial or protozoal cell death while sparing aerobic cells.

The specific dose and duration of Metronidazole Svp Pharma are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. Healthcare providers follow established guidelines to individualize therapy.

Metronidazole is classified as pregnancy category B, indicating that animal studies have not shown risk and there are no adequate human studies. It is generally considered safe when prescribed, but clinicians should evaluate the benefit‑risk ratio for each pregnant or lactating patient.

To order Metronidazole Svp Pharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed), and import documentation.

Metronidazole is often compared with clindamycin, another agent active against anaerobic bacteria. While both cover similar infections, Metronidazole has superior activity against certain protozoa (e.g., Trichomonas) and a lower risk of Clostridioides difficile overgrowth. Choice depends on pathogen susceptibility, patient tolerance, and clinical context.

Metronidazole Svp Pharma should be stored at 2‑8 °C in a refrigerator, protected from light, and never frozen. The solution must be kept in its original container, and any unused portion should be discarded according to local regulations after the recommended storage period.

Metronidazole Svp Pharma is administered intravenously by a qualified healthcare professional. The solution is typically infused over a period of 30‑60 minutes, depending on the prescribed dose and patient tolerance. Infusion equipment should be compatible with the product and maintain aseptic technique throughout administration.

Serious adverse reactions to monitor include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, liver toxicity, and neutropenia. Patients should be instructed to seek immediate medical attention if they experience neurological symptoms, rash, or signs of severe hypersensitivity.

Metronidazole is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. It should also be avoided in individuals with a history of severe alcohol intolerance or those who have experienced a disulfiram‑like reaction. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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