Product image of Metronidazole Unifarma (Metronidazole) supplied by GNH India

Metronidazole Unifarma

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazole Unifarma (Metronidazole)

Metronidazole, the active ingredient in Metronidazole Unifarma, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats a range of anaerobic bacterial and protozoal infections in adult and pediatric patients as prescribed by a healthcare professional.

GNH India supplies Metronidazole Unifarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Unifarma

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic used to manage infections caused by anaerobic bacteria and certain protozoa.

  • Anaerobic bacterial infections: eradicates susceptible anaerobes and reduces infection severity.
  • Bacterial vaginosis: restores normal vaginal flora by targeting Gardnerella and related organisms.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Amoebiasis: clears intestinal Entamoeba histolytica and hepatic abscesses.
  • Intra‑abdominal infections: controls mixed aerobic‑anaerobic infections following surgery or perforation.
  • Pelvic inflammatory disease: treats polymicrobial pelvic infections involving anaerobes.

How It Works

  • Metronidazole enters susceptible anaerobic cells and is reduced by microbial nitroreductases, generating reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to cell death of anaerobic bacteria and protozoa while sparing most aerobic human cells.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: mild to moderate headache.
  • Diarrhea: loose stools during therapy.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Liver toxicity: elevated enzymes or hepatitis.
  • Pancytopenia: reduction in blood cell counts.

Precautions & Warnings

Before initiating therapy, clinicians should assess patient‑specific factors and monitor for potential complications.

  • Renal function: adjust dosing in severe impairment.
  • Hepatic function: monitor liver enzymes during prolonged use.
  • Alcohol consumption: avoid to prevent disulfiram‑like reactions.
  • Central nervous system disorders: use cautiously in patients with seizures or neuropathy.
  • Hypersensitivity: discontinue if allergic signs appear.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole can alter the activity of several co‑administered drugs; careful review is required.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: can raise serum lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Rifampin: induces metabolism, reducing metronidazole exposure.
  • Phenytoin: decreases metronidazole concentrations.
  • Carbamazepine: may lower drug levels.
  • Oral contraceptives: may reduce hormonal efficacy, consider backup contraception.

Frequently Asked Questions

Metronidazole Unifarma is indicated for a variety of anaerobic bacterial and protozoal infections, including intra‑abdominal infections, bacterial vaginosis, trichomoniasis, amoebiasis, pelvic inflammatory disease, and skin or soft‑tissue infections caused by susceptible organisms. The specific condition treated is determined by the prescribing clinician based on diagnostic findings.

Metronidazole is taken up by anaerobic bacteria and certain protozoa, where intracellular nitroreductases reduce its nitro group. This reduction creates reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis, ultimately leading to cell death of the targeted microorganisms while sparing most human cells.

The dosage of Metronidazole Unifarma is individualized by the prescriber according to the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. Healthcare professionals determine the appropriate dose, frequency, and duration for each patient.

Safety data for Metronidazole in pregnancy and lactation are limited, and the drug is generally classified as a precautionary agent. Clinicians weigh potential benefits against possible risks before prescribing to pregnant or nursing individuals, and alternative therapies may be considered when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms and certain protozoa, offering a narrow spectrum that minimizes disruption of normal flora. Compared with broad‑spectrum agents like clindamycin or carbapenems, it provides effective coverage for many anaerobic pathogens with a generally favorable safety profile, though choice depends on susceptibility patterns and infection site.

Metronidazole Unifarma should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and sterility.

Metronidazole Unifarma is supplied as an injectable solution for intravenous infusion. Administration is performed by qualified healthcare personnel under aseptic conditions, following the prescribed infusion rate and duration as directed by the treating physician.

Serious adverse events, though rare, include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, liver toxicity, and pancytopenia. Patients should be monitored for neurological symptoms, skin changes, or signs of bleeding, and therapy should be discontinued if any serious reaction occurs.

Metronidazole Unifarma is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic impairment, those receiving disulfiram, and patients with a history of seizures or peripheral neuropathy unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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