Product image of Metronidazolo Baxter S.P.A. (Metronidazole) supplied by GNH India

Metronidazolo Baxter S.P.A.

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazolo Baxter S.P.A. (Metronidazole)

Metronidazole, the active ingredient in Metronidazolo Baxter S.P.A., is a nitroimidazole antibiotic presented as an intravenous solution for injection use. It treats anaerobic bacterial infections and certain protozoal diseases in adult and pediatric patients as prescribed by a qualified clinician.

GNH India supplies Metronidazolo Baxter S.P.A. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Baxter S.P.A.

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Indications & Clinical Uses

Metronidazole is indicated for a range of anaerobic and protozoal infections. It is employed in the following clinical situations:

  • Anaerobic bacterial infections: eradicates susceptible anaerobes causing intra‑abdominal, skin and soft‑tissue infections.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Clostridioides difficile infection: reduces toxin‑producing C. difficile bacteria in the colon.
  • Pelvic inflammatory disease: targets mixed anaerobic organisms contributing to PID.

How It Works

  • Metronidazole is reduced inside susceptible microorganisms, generating reactive nitro radicals that bind to DNA and other macromolecules. This damage disrupts nucleic acid synthesis and leads to bacterial or protozoal cell death, while sparing most human cells due to limited drug reduction in host tissues.

Side Effects

Metronidazole may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional throbbing or tension headache.
  • Diarrhea: loose stools that may be watery.
  • Abdominal pain: cramping or discomfort in the abdomen.
  • Dizziness: light‑headed feeling, especially on standing.

Serious or Rare Side Effects

  • Seizures: convulsive episodes requiring immediate medical attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin blistering and detachment.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Before initiating Metronidazolo, clinicians should consider several safety measures.

  • Renal function assessment: adjust therapy in patients with impaired kidney function.
  • Hepatic monitoring: check liver enzymes periodically during prolonged use.
  • Alcohol avoidance: advise patients to abstain from alcohol to prevent disulfiram‑like reactions.
  • Pregnancy caution: use only if the potential benefit outweighs risk, after evaluating alternatives.
  • Hematologic vigilance: monitor blood counts in patients with pre‑existing blood disorders.
  • Store at room temperature: keep in original container, protect from moisture and direct light.

Avoid Interactions

Metronidazolo can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may reduce metronidazole plasma concentrations.
  • Cimetidine: can increase metronidazole levels, requiring observation for side effects.

Frequently Asked Questions

Metronidazolo Baxter S.P.A. is an intravenous formulation of metronidazole used to treat anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, Clostridioides difficile infection, and pelvic inflammatory disease. It is administered under medical supervision for infections where susceptible anaerobic or protozoal organisms are identified.

Metronidazole enters susceptible microorganisms and is reduced by their anaerobic metabolic pathways, producing reactive nitro radicals. These radicals bind to DNA and other critical macromolecules, disrupting nucleic acid synthesis and leading to cell death, while human cells are largely unaffected because they lack the necessary reduction environment.

The dosing regimen for Metronidazolo Baxter S.P.A. is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal and hepatic function, and other clinical factors. Healthcare professionals should follow local guidelines and adjust the dose as needed for individual patients.

Safety data for metronidazole during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and risk assessment with their healthcare provider.

To order Metronidazolo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazolo contains metronidazole, a well‑established nitroimidazole with broad activity against anaerobic bacteria and certain protozoa. Compared with alternatives such as tinidazole or ornidazole, metronidazole has a longer history of clinical use, extensive safety data, and is generally less expensive, though individual drug choice depends on pathogen susceptibility and patient tolerance.

Metronidazolo should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Ensure the vial is kept upright, avoid freezing, and discard any solution that appears discolored or contains particles before administration.

Metronidazolo is given by intravenous infusion under the supervision of a qualified healthcare professional. The solution is diluted in an appropriate compatible IV fluid and infused over the recommended period, typically ranging from 30 minutes to several hours, depending on the clinical protocol.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions (including anaphylaxis), Stevens‑Johnson syndrome, hepatic dysfunction, and neutropenia. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and signs of infection or bleeding, and any concerning findings should prompt immediate medical evaluation.

Metronidazolo is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is advised for individuals with severe hepatic impairment, those receiving disulfiram, and patients with a history of severe neurological disorders. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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