Product image of Metronidazolo Bioindustria Lim (Metronidazole) supplied by GNH India

Metronidazolo Bioindustria Lim

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazolo Bioindustria Lim (Metronidazole)

Metronidazole, the active ingredient in Metronidazolo Bioindustria Lim, is a nitroimidazole presented as an injectable solution for intravenous use. It is employed to treat infections caused by susceptible anaerobic bacteria and certain protozoa, and is commonly prescribed for adult and pediatric patients requiring systemic therapy. The drug penetrates tissues and body fluids, achieving therapeutic concentrations in the bloodstream, peritoneal cavity, and central nervous system, which supports its use in a range of intra‑abdominal, gynecologic, and systemic infections. Its broad spectrum activity makes it a valuable option in hospital settings for managing mixed microbial populations.

GNH India supplies Metronidazolo Bioindustria Lim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Bioindustria Lim Laboratorio Italiano Medicinali Spa

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Indications & Clinical Uses

Metronidazole is indicated for infections where anaerobic bacteria or susceptible protozoa are involved. It provides targeted antimicrobial activity across several disease categories.

  • Anaerobic bacterial infections: eradicates susceptible anaerobes, reducing infection severity.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating overgrowth of anaerobic bacteria.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites, treating intestinal and extra‑intestinal disease.
  • Intra‑abdominal infections: provides systemic coverage of anaerobic organisms in peritonitis and abscesses.

How It Works

  • Metronidazole enters susceptible microorganisms and undergoes intracellular reduction to form nitro radical anions. These reactive intermediates interact with DNA, causing strand breakage and loss of helical structure, which inhibits nucleic acid synthesis and leads to cell death. The selective activation in anaerobic cells underlies its efficacy against anaerobic bacteria and certain protozoa while sparing most aerobic host cells.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe. Patients should be monitored for any new symptoms during therapy.

Common Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Diarrhea

Serious or Rare Side Effects

  • Seizures
  • Peripheral neuropathy
  • Severe allergic reactions (anaphylaxis)
  • Stevens‑Johnson syndrome

Precautions & Warnings

Before initiating therapy, clinicians should consider patient‑specific factors and monitor for potential complications.

  • Renal impairment: adjust therapy based on renal function.
  • Hepatic disease: monitor liver enzymes during prolonged use.
  • Alcohol consumption: avoid alcohol due to a disulfiram‑like reaction.
  • Pregnancy: use only if benefits outweigh risks; safety not established.
  • Concomitant neurotoxic drugs: monitor for additive neurotoxicity.
  • Store at below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety. Interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: increased anticoagulant effect; monitor INR closely.
  • Lithium: may raise lithium levels, increasing toxicity risk.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may reduce metronidazole plasma concentrations.
  • Cimetidine: may increase metronidazole levels.
  • Cyclosporine: may elevate cyclosporine concentrations, requiring dose adjustment.

Frequently Asked Questions

Metronidazolo Bioindustria Lim contains metronidazole, an antibiotic indicated for the treatment of anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amoebiasis, and intra‑abdominal infections. It is administered intravenously in hospital settings to achieve rapid systemic concentrations against susceptible microorganisms.

Metronidazole is reduced inside anaerobic microorganisms to generate nitro radical anions. These reactive species damage DNA and inhibit nucleic acid synthesis, leading to bacterial and protozoal cell death. The selective activation in low‑oxygen environments provides targeted antimicrobial activity while sparing most human cells.

The dosing regimen for Metronidazolo Bioindustria Lim is determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. Healthcare professionals should follow local guidelines and adjust the dose as needed.

Safety data for metronidazole during pregnancy are limited, and the drug is classified as pregnancy category unknown. It should be used only when the potential benefits justify the potential risks to the fetus. Caution is also advised during breastfeeding, as the drug can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.

Metronidazole belongs to the nitroimidazole class and offers broad activity against anaerobes and certain protozoa. Compared with alternatives such as tinidazole, it has a similar spectrum but a shorter half‑life, requiring more frequent dosing. Compared with clindamycin, metronidazole provides better coverage of protozoal infections and has a lower risk of Clostridioides difficile colitis.

Store the product at below 25 °C in its original packaging, protecting it from moisture and direct light. Do not freeze the solution. Ensure the container is sealed when not in use and handle according to standard aseptic techniques for intravenous medications.

Metronidazolo Bioindustria Lim is given by intravenous infusion. The solution is typically diluted in compatible IV fluids and administered over a period specified by the prescriber, often 30‑60 minutes, depending on the clinical indication and patient tolerance.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, and rare dermatologic conditions like Stevens‑Johnson syndrome. Patients should be monitored for neurological symptoms, skin changes, and signs of hypersensitivity throughout therapy.

Metronidazolo Bioindustria Lim is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles. Caution is advised for patients with severe hepatic impairment, those in the first trimester of pregnancy, and patients receiving concurrent neurotoxic drugs without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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