Product image of Metronidazolo S.A.L.F. (Metronidazole) supplied by GNH India

Metronidazolo S.A.L.F.

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazolo S.A.L.F. (Metronidazole)

Metronidazole, the active ingredient in Metronidazolo S.A.L.F., is a Nitroimidazole antibiotic presented as an intravenous formulation for systemic use. It is employed to treat a range of anaerobic bacterial and protozoal infections in adult patients, including bacterial vaginosis, pelvic inflammatory disease, and gastrointestinal parasitic diseases.

GNH India supplies Metronidazolo S.A.L.F. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

Metronidazole is used to manage infections caused by anaerobic bacteria and susceptible protozoa.

  • Anaerobic bacterial infections: eradicates the causative anaerobes and resolves infection.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating overgrowth of anaerobes.
  • Pelvic inflammatory disease: treats mixed anaerobic infections of the upper genital tract.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms.
  • Giardiasis: clears Giardia lamblia from the intestinal tract.
  • Amebiasis: destroys Entamoeba histolytica trophozoites, preventing disease progression.

How It Works

  • Metronidazole is reduced within anaerobic microorganisms, generating reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis. This leads to strand breakage and cell death, selectively targeting obligate and facultative anaerobes as well as certain protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional throbbing headache.
  • Dizziness: light‑headedness or vertigo.
  • Abdominal pain: cramping or discomfort.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: anaphylaxis, rash, or swelling.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Neutropenia: reduced white blood cell count.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function assessment: adjust use in impaired kidneys.
  • Hepatic monitoring: watch for liver enzyme elevations.
  • Alcohol avoidance: risk of disulfiram‑like reaction.
  • Pregnancy caution: evaluate risk‑benefit, limited data available.
  • CNS disorders: use carefully in patients with seizures or neuropathy.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, and tachycardia.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: can increase metronidazole plasma concentrations.
  • Oral contraceptives: may reduce contraceptive efficacy, consider backup method.

Frequently Asked Questions

Metronidazolo S.A.L.F. contains metronidazole and is prescribed for anaerobic bacterial infections, bacterial vaginosis, pelvic inflammatory disease, trichomoniasis, giardiasis, and amebiasis. It targets organisms that thrive in low‑oxygen environments, helping to clear infections in the genital, pelvic, and gastrointestinal tracts.

Metronidazole is taken up by anaerobic microbes and reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, causing strand breakage and cell death. The process selectively affects anaerobic bacteria and certain protozoa while sparing aerobic cells.

The dosage of Metronidazolo S.A.L.F. is determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. Only a qualified healthcare professional should set the appropriate regimen.

Safety data for metronidazole in pregnancy are limited, and the drug should be used only if the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult a healthcare provider, as metronidazole can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazole belongs to the nitroimidazole class, offering activity against anaerobes and protozoa that many beta‑lactam antibiotics lack. Compared with broad‑spectrum agents, it provides targeted coverage for specific infections such as bacterial vaginosis and giardiasis, often with a lower risk of promoting resistant aerobic flora.

Metronidazolo S.A.L.F. should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Ensure the vial or ampoule is kept upright and sealed until use, and discard any product that appears discolored or cloudy.

The product is supplied for intravenous injection. It is administered by a qualified healthcare professional, typically as a slow infusion into a vein. The exact rate and duration depend on the prescribed dose and the clinical setting.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatic toxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin reactions, and liver function abnormalities during therapy.

Metronidazolo S.A.L.F. is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for individuals with severe hepatic impairment, a history of seizures, or those who are currently consuming alcohol.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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