Product image of Metronidazolo Same Savoma Medicinali (Metronidazole) supplied by GNH India

Metronidazolo Same Savoma Medicinali

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazolo Same Savoma Medicinali (Metronidazole)

Metronidazole, the active ingredient in Metronidazolo Same Savoma, is a Nitroimidazole presented as a topical formulation for skin use. It is employed to treat certain bacterial skin conditions and inflammatory disorders such as rosacea, acne, and other anaerobic infections of the skin.

GNH India supplies Metronidazolo Same Savoma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets. The product meets EU standards and is manufactured under strict Good Manufacturing Practices.

Manufacturer / TM Owner

Savoma Medicinali Spa

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Indications & Clinical Uses

Metronidazole is used for topical treatment of skin conditions caused by anaerobic bacteria or inflammation.

  • Rosacea: reduces inflammatory lesions and erythema associated with the condition.
  • Bacterial skin infections: eradicates susceptible anaerobic bacteria, promoting lesion healing.
  • Acne: decreases bacterial colonisation and inflammation, improving lesion count.

How It Works

  • Metronidazole enters anaerobic microbial cells where it undergoes reduction by ferredoxin‑type proteins to generate reactive nitro radical anions. These radicals interact with DNA, causing strand breaks and loss of helical stability, and also inhibit nucleic acid synthesis. The resulting damage leads to bacterial cell death, while anti‑inflammatory properties reduce cytokine production in skin tissues. The drug also modulates neutrophil chemotaxis, contributing to its efficacy in inflammatory dermatoses.

Side Effects

Topical metronidazole may cause a range of local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: mild redness, itching or burning at the application site.
  • Dryness: temporary dryness or peeling of the treated skin.
  • Discoloration: mild hyperpigmentation or hypopigmentation of the area.
  • Taste disturbance: occasional metallic taste when applied near the mouth.

Serious or Rare Side Effects

  • Allergic reaction: rash, swelling, or hives indicating hypersensitivity.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Neurological effects: peripheral neuropathy or seizures in rare cases.
  • Hematologic changes: unexplained anemia or leukopenia.

Precautions & Warnings

When using topical metronidazole, several precautions should be observed to ensure safety and effectiveness.

  • Pregnancy: consult a healthcare professional before use, as safety data are limited.
  • Breastfeeding: discuss potential risks with a physician, as drug may be excreted in milk.
  • Skin integrity: avoid application on open wounds or severely damaged skin.
  • Concomitant therapy: inform the prescriber of other topical or systemic antibiotics being used.
  • Allergies: discontinue if signs of hypersensitivity appear.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with other medicines, altering its efficacy or increasing toxicity.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing and nausea.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cytochrome P450 inducers (e.g., rifampicin, carbamazepine): may reduce metronidazole concentrations.
  • Anticonvulsants (e.g., phenytoin): may require dose adjustment.
  • Oral contraceptives: possible reduction in effectiveness, advise additional contraceptive measures.

Frequently Asked Questions

Metronidazolo Same Savoma is a topical formulation of metronidazole indicated for the treatment of rosacea, bacterial skin infections caused by susceptible anaerobic organisms, and inflammatory acne. It helps reduce lesions, redness, and bacterial colonisation on the skin.

Metronidazole penetrates anaerobic bacterial cells and is reduced to reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis, leading to bacterial death. In addition, it exerts anti‑inflammatory effects by modulating cytokine release and neutrophil activity, which contributes to improvement of inflammatory skin disorders.

The appropriate dose and frequency of Metronidazolo Same Savoma are determined by the prescribing healthcare professional based on the specific condition, severity, patient age, and other clinical factors. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Safety data for topical metronidazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with other topical antibiotics such as clindamycin or erythromycin, metronidazole offers both antibacterial and anti‑inflammatory actions, making it particularly useful for rosacea and acne where inflammation is prominent. Its spectrum is focused on anaerobic organisms, and it generally has a favorable tolerability profile, though individual response may vary.

Metronidazolo Same Savoma should be stored below 25 °C in its original packaging, protected from moisture and direct light. Keep the container tightly closed when not in use and avoid exposing the product to excessive heat or humidity to maintain its stability.

The product is applied topically to the affected skin area, typically once or twice daily as directed by the prescriber. A thin layer should be spread gently and allowed to dry before covering the area with clothing or bandages, unless otherwise instructed.

Serious adverse reactions, although rare, include severe allergic responses such as rash, swelling, or hives, and potentially life‑threatening conditions like Stevens‑Johnson syndrome. Neurological symptoms such as peripheral neuropathy or seizures also warrant immediate medical attention.

Individuals with a known hypersensitivity to metronidazole or any component of the formulation should avoid using the product. It is also contraindicated on severely damaged or open wounds, and caution is advised in patients with significant liver disease or those taking interacting medications without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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