Product image of Metrosa (Metronidazole) supplied by GNH India

Metrosa

Active Ingredient:
Metronidazole
Origin:
EU

Metrosa (Metronidazole)

Metronidazole, the active ingredient in Metrosa, is a nitroimidazole antibiotic presented as a topical formulation for skin use. It is employed to manage inflammatory skin conditions caused by anaerobic bacteria and protozoa, most notably rosacea, in adult patients.

GNH India supplies Metrosa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

1
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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Rosacea: reduces inflammatory lesions and erythema on the face.
  • Bacterial vaginosis: eradicates anaerobic bacterial overgrowth in the vaginal flora.
  • Trichomoniasis: eliminates the protozoan parasite Trichomonas vaginalis.
  • Anaerobic skin infections: treats localized infections caused by susceptible anaerobes.

How It Works

  • Metronidazole penetrates microbial cells and undergoes enzymatic reduction under anaerobic conditions, generating nitro radicals that interact with DNA. These reactive intermediates cause strand breakage and inhibit nucleic acid synthesis, leading to irreversible damage and cell death of anaerobic bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions when applied to the skin.

Common Side Effects

  • Skin irritation: mild redness or burning at the application site.
  • Dryness: localized skin dryness or flaking.
  • Itching: pruritus around the treated area.
  • Discoloration: temporary hyperpigmentation or hypopigmentation.
  • Stinging sensation: transient sharp sensation upon application.
  • Contact dermatitis: mild allergic skin reaction.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Stevens‑Johnson syndrome: rare but serious mucocutaneous eruption.
  • Toxic epidermal necrolysis: extensive skin detachment.
  • Systemic absorption leading to neurotoxicity: dizziness or seizures (very rare with topical use).

Precautions & Warnings

When using Metrosa, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Known hypersensitivity: avoid if allergic to metronidazole or other nitroimidazoles.
  • Concurrent alcohol use: limit intake as irritation may increase.
  • Sun exposure: protect treated skin from excessive UV radiation.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several systemic agents; topical exposure generally has limited systemic interaction, but caution is advised.

Major Interactions (Avoid)

  • Alcohol: may cause severe skin irritation and a disulfiram‑like reaction.
  • Warfarin: potential increase in anticoagulant effect.
  • Lithium: risk of heightened lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma levels.
  • Oral contraceptives: possible reduction in efficacy.
  • Phenytoin: may alter metabolism of both drugs.

Frequently Asked Questions

Metrosa, containing metronidazole, is primarily used as a topical treatment for rosacea, a chronic inflammatory skin condition. It may also be employed in managing localized anaerobic skin infections and, in systemic forms, for bacterial vaginosis, trichomoniasis, and other anaerobic bacterial infections as directed by a healthcare professional.

Metronidazole penetrates microbial cells and, under anaerobic conditions, is reduced to reactive nitro radicals. These radicals bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, which leads to death of anaerobic bacteria and protozoa responsible for the targeted skin condition.

The dosage of Metrosa is determined by the prescribing clinician based on the specific indication, severity of the condition, and patient factors. The prescriber will provide detailed instructions on the amount to apply, frequency, and duration of therapy.

Safety of topical metronidazole during pregnancy or lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Metrosa.

To order Metrosa, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metrosa (topical metronidazole) is a well‑established option for mild to moderate papulopustular rosacea, offering anti‑inflammatory and antimicrobial effects. Alternative agents include azelaic acid, ivermectin cream, and doxycycline (oral). Choice of therapy depends on disease severity, patient tolerance, and physician preference.

Metrosa should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and extreme heat. Ensure the lid is tightly closed to maintain product stability.

Metrosa is applied topically to the affected skin area. Clean and gently pat the skin dry, then spread a thin layer of the product as directed by the prescriber, usually once or twice daily. Avoid contact with eyes, mucous membranes, and broken skin unless instructed otherwise.

Serious risks, though rare with topical use, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and toxic epidermal necrolysis. Patients should discontinue use and seek immediate medical attention if they experience widespread rash, blistering, swelling, or difficulty breathing.

Metrosa should not be used by individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. It is also contraindicated on severely damaged or ulcerated skin unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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