Product image of Metrosa (Metronidazole) supplied by GNH India

Metrosa

Active Ingredient:
Metronidazole
Origin:
EU

Metrosa (Metronidazole)

Metronidazole, the active ingredient in Metrosa, is a nitroimidazole antibiotic presented as a topical formulation for cutaneous use. It is employed to manage certain inflammatory skin conditions such as acne vulgaris and rosacea.
GNH India supplies Metrosa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

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Indications & Clinical Uses

Metrosa, a nitroimidazole antibiotic, is applied to skin disorders where bacterial or protozoal involvement contributes to inflammation.

  • Acne vulgaris: reduces inflammatory lesions and bacterial colonisation on the skin.
  • Rosacea: diminishes papules, pustules and erythema associated with the condition.
  • Skin infections (e.g., susceptible bacterial or protozoal lesions): limits microbial growth and alleviates local inflammation.

How It Works

  • Metronidazole is reduced within susceptible microorganisms, generating reactive nitro radicals that cause DNA strand breakage and inhibit nucleic acid synthesis, ultimately leading to cell death of anaerobic bacteria and protozoa.

Side Effects

Metrosa may cause local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: mild burning or stinging at the application site.
  • Dryness: increased transepidermal water loss causing flaky skin.
  • Itching: pruritus localized to treated areas.
  • Redness: transient erythema after application.
  • Allergic contact dermatitis: localized rash with swelling.
  • Peeling: desquamation of the outer skin layer.

Serious or Rare Side Effects

  • Anaphylaxis: severe, systemic allergic reaction requiring emergency care.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: extensive skin detachment.
  • Severe photosensitivity: exaggerated sunburn response.
  • Neurotoxicity: peripheral neuropathy or seizures with systemic absorption.
  • Hemolytic anemia in patients with G6PD deficiency.
  • Severe systemic infection: rare but possible if absorption is high.

Precautions & Warnings

Before using Metrosa, consider the following safety measures.

  • Pregnancy: consult a prescriber; safety data are limited.
  • Breastfeeding: use with caution; metronidazole may be excreted in milk.
  • Skin integrity: avoid application on open wounds or severely damaged skin.
  • Alcohol consumption: limit intake to reduce risk of disulfiram‑like reactions.
  • Hypersensitivity: discontinue immediately if signs of allergic reaction appear.
  • Store at below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Metrosa can interact with other substances; monitor as indicated.

Major Interactions (Avoid)

  • Alcohol: may provoke a disulfiram‑like reaction with flushing and nausea.
  • Warfarin: can potentiate anticoagulant effects, increasing bleeding risk.
  • Lithium: concurrent use may heighten neurotoxic potential.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma concentrations.
  • Phenobarbital: can reduce metronidazole efficacy through enzyme induction.
  • Oral contraceptives: possible reduction in hormonal effectiveness; consider backup contraception.

Frequently Asked Questions

Metrosa is a prescription‑only topical medication that contains metronidazole. It is primarily used to treat inflammatory skin conditions such as acne vulgaris and rosacea, where it helps reduce lesions, redness, and bacterial colonisation on the skin.

Metronidazole is taken up by susceptible microorganisms and undergoes reduction of its nitro group. This process creates reactive radicals that damage DNA and inhibit nucleic acid synthesis, leading to microbial cell death and reduction of inflammation in the treated area.

The dosage of Metrosa is determined by the prescribing clinician based on the severity of the skin condition, patient age, and tolerance. The prescriber will specify the amount to apply, frequency, and duration of therapy on the product label.

Safety data for topical metronidazole in pregnancy are limited, so use only if the potential benefit outweighs any risk and after consulting a healthcare professional. While small amounts may be excreted in breast milk, caution is advised and a prescriber should evaluate the need for treatment while breastfeeding.

To order Metrosa, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Metrosa (topical metronidazole) offers anti‑inflammatory and antimicrobial activity, making it useful for rosacea and mild‑to‑moderate acne. Compared with topical clindamycin, metronidazole has a lower risk of antibiotic resistance. Oral tetracyclines provide systemic action but carry higher systemic side‑effect profiles. Choice depends on disease severity, patient preference and physician assessment.

Metrosa should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Keep the container tightly closed when not in use and out of reach of children. Do not freeze or expose the product to excessive heat.

Metrosa is applied topically to clean, dry skin. The prescriber will advise the amount (usually a thin film) and frequency, commonly twice daily. It should be spread gently over the affected area and allowed to absorb before applying other skin products.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and rare systemic neurotoxicity if significant absorption occurs. Patients should seek immediate medical attention if they experience swelling, blistering, widespread rash, or neurological symptoms.

Metrosa should not be used by individuals with known hypersensitivity to metronidazole or any component of the formulation. It is also contraindicated on severely broken skin, in patients with G6PD deficiency who may develop hemolysis, and in those where a prescriber determines the risks outweigh the benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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