Product image of Metrosa (Metronidazole) supplied by GNH India

Metrosa

Active Ingredient:
Metronidazole
Origin:
EU

Metrosa (Metronidazole)

Metronidazole, the active ingredient in Metrosa, is a nitroimidazole presented as a topical formulation for skin use. It is used to manage inflammatory skin conditions such as rosacea in adults.
GNH India supplies Metrosa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

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Indications & Clinical Uses

Metronidazole is indicated for the treatment of inflammatory skin disorders, particularly those involving anaerobic bacterial overgrowth.

  • Rosacea: reduces papules, pustules and erythema associated with facial rosacea.

How It Works

  • Metronidazole penetrates microbial cells and undergoes reduction of its nitro group, generating nitro radicals that damage DNA and inhibit nucleic acid synthesis in anaerobic microorganisms, leading to bacterial cell death and reduction of inflammatory mediators in the skin.

Side Effects

Metrosa may cause a range of skin‑related adverse reactions.

Common Side Effects

  • Skin irritation: mild redness or discomfort at the application site
  • Dryness: localized dryness or flaking of the skin
  • Burning sensation: transient warmth or stinging after application
  • Itching: pruritus localized to treated area
  • Peeling: superficial desquamation of the epidermis
  • Hyperpigmentation: temporary darkening of the skin

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or difficulty breathing
  • Severe dermatitis: extensive rash or blistering
  • Photosensitivity: heightened skin sensitivity to sunlight
  • Contact dermatitis: persistent inflammation at the site
  • Systemic effects: rare nausea or headache if absorbed in large amounts
  • Anaphylaxis: life‑threatening allergic response requiring emergency care

Precautions & Warnings

When using Metrosa, consider the following safety measures.

  • Allergy assessment: confirm no known hypersensitivity to metronidazole or nitroimidazoles
  • Application area: avoid use on broken, ulcerated, or severely inflamed skin
  • Duration of therapy: limit use to the period prescribed by a healthcare professional
  • Concomitant products: avoid simultaneous use of other topical irritants unless directed
  • Monitoring: watch for signs of allergic reaction or worsening skin condition
  • Store at below 25°C: keep in original packaging, protect from moisture and direct sunlight

Avoid Interactions

Metrosa may interact with other substances; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Alcohol consumption: risk of disulfiram‑like reaction causing flushing and nausea
  • Systemic metronidazole: concurrent systemic therapy may increase systemic exposure

Moderate Interactions (Monitor Closely)

  • Other topical antibiotics: potential additive irritation
  • Topical corticosteroids: may alter absorption or efficacy
  • Warfarin: theoretical increase in anticoagulant effect if systemic absorption occurs
  • Anticonvulsants: possible interaction with hepatic enzymes

Frequently Asked Questions

Metrosa is a topical formulation containing metronidazole that is primarily used to treat rosacea, an inflammatory skin condition characterized by facial redness, papules, and pustules. It helps reduce lesions and improve skin appearance when applied as directed by a healthcare professional.

Metronidazole exerts its effect by entering microbial cells and forming nitro radicals that damage DNA and inhibit nucleic acid synthesis in anaerobic bacteria. This antimicrobial action, combined with anti‑inflammatory properties, reduces the bacterial load and inflammatory mediators that contribute to rosacea lesions.

The dosing regimen for Metrosa is determined by the prescribing clinician based on the severity of the rosacea and the patient’s response. Typically, a thin layer is applied to the affected facial areas once or twice daily, but the exact frequency and duration should follow the healthcare provider’s instructions.

Safety data for topical metronidazole during pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any unknown risks. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician before starting treatment.

To order Metrosa, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Metrosa (topical metronidazole) belongs to the nitroimidazole class and offers both antimicrobial and anti‑inflammatory effects. Compared with azelaic acid or ivermectin creams, metronidazole is generally well tolerated and effective for mild to moderate rosacea, though individual response varies and some patients may prefer alternative agents based on side‑effect profiles.

Metrosa should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid freezing. If the cream appears discolored or separated, discard it and obtain a new supply.

Metrosa is applied topically to clean, dry skin. A thin layer is spread evenly over the affected facial areas, usually once or twice daily, as directed by a healthcare professional. Hands should be washed before and after application, and the treated area should not be covered with occlusive dressings unless advised.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, extensive dermatitis, and photosensitivity leading to exaggerated sunburn. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, widespread rash, or blistering after using the product.

Metrosa should not be used by individuals with a known hypersensitivity to metronidazole, other nitroimidazoles, or any component of the formulation. It is also contraindicated on severely damaged, ulcerated, or infected skin unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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