Product image of Metrosa (Metronidazole) supplied by GNH India

Metrosa

Active Ingredient:
Metronidazole
Origin:
EU

Metrosa (Metronidazole)

Metronidazole, the active ingredient in Metrosa, is a nitroimidazole antibiotic presented as a topical formulation for cutaneous use. It treats rosacea, acne vulgaris and certain skin infections in patients requiring prescription therapy.

GNH India supplies Metrosa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic that targets anaerobic bacteria and protozoa in skin conditions.

  • Rosacea: reduces inflammatory lesions and erythema associated with the condition.
  • Acne vulgaris: decreases bacterial colonization and inflammation of acne lesions.
  • Skin infections: treats susceptible bacterial skin infections, including those caused by anaerobic organisms.

How It Works

  • Metronidazole is reduced within anaerobic microbial cells to nitro‑radical anions that bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis. The resulting damage prevents replication and leads to cell death, while also exerting anti‑inflammatory effects on host tissues.

Side Effects

Metronidazole may cause a range of cutaneous and systemic adverse reactions.

Common Side Effects

  • Skin irritation: mild redness or burning at the application site.
  • Pruritus: itching of the treated area.
  • Dryness: localized dryness or peeling.
  • Taste alteration: metallic taste when absorbed.
  • Nausea: occasional mild nausea.
  • Headache: transient headache.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.
  • Peripheral neuropathy: numbness or tingling in extremities.
  • Seizures: rare central nervous system events.
  • Hepatotoxicity: signs of liver dysfunction such as jaundice.
  • Blood dyscrasias: unexplained bruising or low blood counts.

Precautions & Warnings

When prescribing or dispensing Metrosa, consider the following precautions to ensure safe use.

  • Pregnancy: assess risk‑benefit, as safety data are limited.
  • Breastfeeding: evaluate potential exposure to infant.
  • Liver disease: use with caution in patients with hepatic impairment.
  • Alcohol consumption: avoid alcohol during therapy due to disulfiram‑like reaction.
  • Drug hypersensitivity: discontinue if signs of severe allergy appear.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and nausea.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma concentrations.
  • Phenobarbital: may reduce metronidazole levels, decreasing effectiveness.
  • Oral contraceptives: possible reduction in contraceptive efficacy.

Frequently Asked Questions

Metrosa is prescribed for dermatological conditions that involve anaerobic bacteria or inflammation, specifically rosacea, acne vulgaris and certain bacterial skin infections. It is applied topically to reduce lesions, redness and bacterial colonisation in these indications.

Metronidazole enters anaerobic microbial cells and is reduced to reactive nitro‑radical anions. These metabolites bind to DNA, causing strand breakage and blocking nucleic acid synthesis, which leads to microbial cell death. The drug also has anti‑inflammatory properties that help calm skin inflammation.

The exact dosage and frequency of Metrosa are determined by the prescribing clinician based on the severity of the skin condition, the area to be treated and patient‑specific factors. No standard dose is provided here; the prescriber will set the appropriate regimen.

Safety data for metronidazole in pregnancy and lactation are limited. Clinicians should weigh potential benefits against possible risks before prescribing to pregnant or nursing women, and discuss any concerns with the patient.

To request Metrosa, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Metrosa (metronidazole) belongs to the nitroimidazole class and offers both antimicrobial and anti‑inflammatory effects, which differ from retinoids or azelaic acid that act primarily on keratinocyte turnover. It is often chosen when bacterial involvement or inflammation is prominent, and it may be used in combination with other agents for synergistic benefit.

Metrosa should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct light to maintain stability and potency.

Metrosa is a topical preparation intended for cutaneous use. Apply a thin layer to the affected skin area as directed by the prescriber, typically once or twice daily, and wash hands after application unless treating the hands themselves.

Serious adverse reactions include severe allergic responses such as anaphylaxis, peripheral neuropathy, seizures, hepatotoxicity and blood dyscrasias. Patients should seek immediate medical attention if they experience symptoms like rash, swelling, numbness, jaundice or unexplained bruising.

Metrosa is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic impairment, those who consume alcohol heavily, and pregnant or lactating women unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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