Product image of Metycor (Metyrapone) supplied by GNH India

Metycor

Active Ingredient:
Metyrapone
Origin:
EU

Metycor (Metyrapone)

Metyrapone, the active ingredient in Metycor, is a 11β-hydroxylase inhibitor presented as a tablet for oral use. It is used in diagnostic testing of adrenal insufficiency and in the treatment of Cushing's syndrome in adults.

GNH India supplies Metycor as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Esteve Pharmaceuticals, S.A.

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Indications & Clinical Uses

Metyrapone acts on adrenal cortisol synthesis and is employed in specific endocrine indications.

  • Diagnostic testing of adrenal insufficiency: helps assess adrenal reserve by blocking cortisol production for stimulation testing.
  • Treatment of Cushing's syndrome: reduces excess cortisol synthesis to control hypercortisolism.
  • Evaluation of ACTH-dependent disorders: assists in differentiating pituitary from ectopic ACTH sources during endocrine work‑up.

How It Works

  • Metyrapone inhibits the enzyme 11β‑hydroxylase in the adrenal cortex, preventing the conversion of 11‑deoxycortisol to cortisol. By blocking this final step of cortisol biosynthesis, it lowers circulating cortisol levels and allows clinicians to evaluate adrenal function or manage conditions characterized by cortisol excess.

Side Effects

Metyrapone may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea
  • Dizziness
  • Fatigue
  • Abdominal discomfort

Serious or Rare Side Effects

  • Adrenal crisis due to abrupt cortisol depletion
  • Severe hypotension
  • Hyponatremia or electrolyte imbalance
  • Allergic reactions such as rash or angioedema
  • Hepatic dysfunction

Precautions & Warnings

When using Metyrapone, clinicians should consider several safety measures.

  • Monitor cortisol levels: regular testing is needed to avoid adrenal insufficiency.
  • Assess adrenal function before discontinuation: tapering may be required.
  • Use caution in patients with cardiovascular disease: hypotensive effects can be pronounced.
  • Avoid in individuals with known hypersensitivity to metyrapone or excipients.
  • Adjust use in hepatic impairment: liver function should be evaluated.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metyrapone can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Ketoconazole (strong CYP3A4 inhibitor): may increase metyrapone plasma concentrations.
  • Concurrent glucocorticoids: can mask signs of adrenal insufficiency.
  • Rifampin or other CYP3A4 inducers: may markedly reduce metyrapone effectiveness.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive hypotensive effect may occur.
  • Diuretics: can exacerbate electrolyte disturbances.
  • Oral contraceptives: hormonal balance may be altered, requiring monitoring.

Frequently Asked Questions

Metycor contains metyrapone and is used primarily for diagnostic testing of adrenal insufficiency and for the medical management of Cushing's syndrome, conditions that involve abnormal cortisol production.

Metyrapone blocks the enzyme 11β‑hydroxylase in the adrenal cortex, preventing the final step of cortisol synthesis. This inhibition lowers cortisol levels and allows clinicians to evaluate adrenal function or treat cortisol excess.

The dosage of Metycor is determined by the prescribing clinician based on the specific indication, patient age, weight, and clinical response. Only a qualified healthcare professional should set the dosing regimen.

Safety data for metyrapone in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Metycor, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metyrapone is a selective 11β‑hydroxylase inhibitor, whereas other agents such as ketoconazole inhibit multiple steroidogenic enzymes. Metyrapone’s targeted mechanism can provide more precise control of cortisol levels, but the choice of therapy depends on individual patient factors and physician judgment.

Metycor should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, heat and direct sunlight to maintain stability.

Metycor is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing and frequency depend on the therapeutic goal and patient response.

The most serious risks include adrenal crisis due to rapid cortisol depletion, severe hypotension, hyponatremia, and rare allergic reactions such as rash or angioedema. Patients should be monitored closely for these events.

Metycor should be avoided in individuals with known hypersensitivity to metyrapone or any of its excipients, and it should be used with caution in patients with severe cardiovascular disease, uncontrolled hypertension, or significant liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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