Product image of Mexolan (Meloxicam) supplied by GNH India

Mexolan

Active Ingredient:
Meloxicam
Origin:
EU

Mexolan (Meloxicam)

Meloxicam, the active ingredient in Mexolan, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable formulation for intramuscular use. It treats pain and inflammation associated with osteoarthritis, rheumatoid arthritis and other musculoskeletal conditions in adults.

GNH India supplies Mexolan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Meloxicam is used to manage inflammatory and painful conditions affecting the musculoskeletal system.

  • Pain relief: Provides symptomatic reduction of mild to moderate pain linked to inflammatory disorders.
  • Osteoarthritis: Improves joint function and decreases pain in degenerative joint disease.
  • Rheumatoid arthritis: Reduces joint swelling and stiffness in autoimmune arthritis.
  • Musculoskeletal inflammation: Alleviates inflammation in soft‑tissue injuries and other inflammatory musculoskeletal conditions.

How It Works

  • Meloxicam preferentially inhibits cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis leads to diminished inflammation, pain signaling, and fever responses while sparing COX‑1 mediated protective gastric functions to a greater extent than non‑selective NSAIDs.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Injection site reactions: redness, swelling, or pain at the intramuscular site.
  • Peripheral edema: mild swelling of the lower limbs.
  • Elevated liver enzymes: mild, transient increases.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Cardiovascular events: myocardial infarction or stroke.
  • Renal impairment or failure.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: hepatitis or liver failure.
  • Anaphylactic or severe hypersensitivity reactions.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety factors.

  • Renal function assessment: adjust use in patients with impaired kidney function.
  • Gastrointestinal risk: evaluate history of ulcers or bleeding before prescribing.
  • Cardiovascular evaluation: use caution in patients with established heart disease.
  • Hepatic monitoring: check liver enzymes periodically during treatment.
  • Hypersensitivity screening: avoid in individuals with known meloxicam or NSAID allergy.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Meloxicam may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and renal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding potential.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal clearance of meloxicam.
  • ACE inhibitors or ARBs: may diminish antihypertensive effect and affect kidney function.
  • Methotrexate: potential for increased methotrexate toxicity.

Frequently Asked Questions

Mexolan contains meloxicam, an NSAID indicated for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis and other musculoskeletal inflammatory conditions. It helps reduce joint swelling, stiffness and discomfort in adult patients.

Meloxicam works by preferentially inhibiting the cyclooxygenase‑2 (COX‑2) enzyme, which lowers the production of prostaglandins—chemical mediators that promote inflammation, pain, and fever. By reducing prostaglandin levels, meloxicam diminishes the inflammatory response and associated pain.

The specific dose of Mexolan is determined by the prescribing clinician based on the patient’s condition, severity, and individual health factors. Healthcare professionals set the appropriate dosage and administration schedule according to clinical guidelines.

Safety data for meloxicam in pregnancy and lactation are limited. It is generally advised to avoid use unless clearly needed and prescribed by a qualified healthcare provider, as potential risks to the fetus or infant cannot be ruled out.

To request Mexolan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Mexolan (meloxicam) offers relatively selective COX‑2 inhibition compared with non‑selective NSAIDs, which may result in a lower incidence of gastrointestinal side effects while still providing effective analgesic and anti‑inflammatory action. However, individual response and safety profiles vary, so clinicians choose the most appropriate NSAID based on patient risk factors.

Mexolan should be stored at ambient temperature, below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the vial or ampoule remains sealed until use.

Mexolan is supplied as an injectable formulation for intramuscular administration. A qualified healthcare professional injects the prescribed dose into a suitable muscle site, following aseptic technique and standard injection guidelines.

Serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as myocardial infarction or stroke, renal impairment or failure, severe skin reactions (e.g., Stevens‑Johnson syndrome), hepatic dysfunction, and anaphylactic reactions. Patients should be monitored for any signs of these conditions.

Mexolan is contraindicated in individuals with known hypersensitivity to meloxicam or other NSAIDs, those with active gastrointestinal ulceration or bleeding, patients with severe renal or hepatic impairment, and persons with a history of cardiovascular thrombotic events unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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