Product image of Mezym (Amylase, Lipase, Protease) supplied by GNH India

Mezym

Active Ingredient:
Amylase, Lipase, Protease
Origin:
EU

Mezym (Amylase, Lipase, Protease)

Amylase, Lipase, Protease, the active ingredient in Mezym, is a digestive enzyme supplement presented as an oral dosage form for oral use. It aids the breakdown of carbohydrates, fats, and proteins and is indicated for conditions such as exocrine pancreatic insufficiency and other malabsorption disorders.

GNH India supplies Mezym as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide. Our distribution network ensures consistent quality and regulatory compliance across regions. We adhere to EU pharmacopeial standards and provide comprehensive documentation for import and customs clearance.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Mezym, a digestive enzyme supplement, acts on the gastrointestinal digestive process to improve nutrient breakdown.

  • Exocrine pancreatic insufficiency: enhances digestion of fats, proteins and carbohydrates by supplying deficient pancreatic enzymes.
  • Malabsorption syndromes: supports absorption of nutrients in conditions where endogenous enzyme production is inadequate.
  • Chronic digestive disorders: assists symptomatic relief in patients with longstanding pancreatic or gastrointestinal disease.

How It Works

  • Mezym provides exogenous amylase, lipase, and protease that remain active in the gastrointestinal lumen. These enzymes catalyze the hydrolysis of starches, triglycerides, and peptide bonds, respectively, thereby supplementing endogenous pancreatic secretions and facilitating the conversion of macronutrients into absorbable monomers.

Side Effects

Adverse reactions may occur with any oral enzyme preparation.

Common Side Effects

  • Abdominal discomfort: mild pain or cramping in the stomach area.
  • Flatulence: increased intestinal gas production.
  • Diarrhea: loose stools occurring after dosing.
  • Nausea: feeling of queasiness.
  • Constipation: reduced bowel movements.
  • Taste alteration: temporary change in flavor perception.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Severe abdominal pain: persistent or worsening pain.
  • Pancreatitis exacerbation: worsening of underlying pancreatic inflammation.
  • Eosinophilia: elevated eosinophil count in blood.
  • Serum amylase elevation: laboratory indication of pancreatic irritation.
  • Persistent vomiting: inability to retain oral intake.

Precautions & Warnings

Before initiating Mezym, consider the following safety measures.

  • Assess pancreatic function: confirm enzyme deficiency or insufficiency.
  • Monitor for intolerance: watch for gastrointestinal upset after the first doses.
  • Hypersensitivity caution: avoid in patients with known allergy to any of the enzyme components.
  • Active gastrointestinal bleeding: defer use until bleeding is controlled.
  • Do not exceed prescribed dose: follow prescriber instructions precisely.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Enzyme supplements can interact with other medicines, affecting their absorption or activity.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: may bind enzymes and reduce their effectiveness.
  • Orlistat: inhibits fat digestion, potentially diminishing lipase activity.
  • High‑dose proton pump inhibitors: may alter gastric pH and affect enzyme activation.

Moderate Interactions (Monitor Closely)

  • Warfarin: changes in vitamin K absorption could affect anticoagulation control.
  • Oral hypoglycemics: altered carbohydrate breakdown may influence blood glucose levels.
  • Corticosteroids: increased risk of gastrointestinal irritation when combined.

Frequently Asked Questions

Mezym is an oral digestive enzyme supplement that provides amylase, lipase, and protease. It is used to support the breakdown and absorption of carbohydrates, fats, and proteins in patients with exocrine pancreatic insufficiency, malabsorption syndromes, or other chronic digestive disorders where endogenous enzyme production is inadequate.

The three enzymes in Mezym act in the gastrointestinal tract: amylase hydrolyzes starches into simple sugars, lipase splits triglycerides into fatty acids and glycerol, and protease cleaves peptide bonds to release amino acids. By supplying these enzymes externally, Mezym supplements the body's own pancreatic secretions, enhancing nutrient digestion and absorption.

The dosage of Mezym is individualized. A qualified prescriber determines the appropriate amount based on the patient’s degree of pancreatic insufficiency, body weight, dietary intake, and clinical response. Patients should follow the prescribing clinician’s instructions and not adjust the dose without medical guidance.

Safety data for Mezym in pregnancy and lactation are limited. Because the product contains enzymes that are not systemically absorbed in significant amounts, it is generally considered low risk, but the prescriber should evaluate the benefit‑risk balance for each individual. Women who are pregnant or nursing should discuss use with their healthcare provider.

To request Mezym, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.

Mezym contains a combination of amylase, lipase, and protease, similar to many pancreatic enzyme replacement therapies. Compared with single‑enzyme preparations, Mezym offers a broader spectrum of macronutrient digestion. The specific enzyme activity units, formulation, and excipients may differ from competitors, influencing factors such as dosing frequency, tolerability, and cost. Clinicians select the product that best matches the patient’s clinical profile.

Mezym should be stored at ambient temperature, preferably below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture, direct sunlight, and excessive heat. Do not store in a bathroom or near a kitchen stove. Ensure the container is tightly closed after each use to maintain enzyme stability.

Mezym is taken orally, usually with meals or snacks that contain the nutrients to be digested. The tablets or capsules should be swallowed whole with a full glass of water unless the prescribing information advises otherwise. Timing the dose with food maximizes the enzymes’ contact with ingested macronutrients, improving their effectiveness.

The most serious risks include allergic reactions that can progress to anaphylaxis, severe abdominal pain indicating possible pancreatitis exacerbation, and rare cases of eosinophilia or significant serum amylase elevation. Patients should seek immediate medical attention if they experience swelling of the face or throat, difficulty breathing, persistent vomiting, or intense abdominal pain.

Mezym is contraindicated in individuals with a known hypersensitivity to any of its enzyme components or excipients. It should also be avoided in patients with active gastrointestinal bleeding, severe acute pancreatitis, or those who are unable to swallow oral dosage forms. The prescriber must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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