Product image of Mezym (Pancreas Powder) supplied by GNH India

Mezym

Active Ingredient:
Pancreas Powder
Origin:
EU

Mezym (Pancreas Powder)

Pancreas Powder, the active ingredient in Mezym, is a digestive enzyme presented as a pancreatic enzyme preparation for oral use. It facilitates the digestion of fats, proteins, and carbohydrates in patients with exocrine pancreatic insufficiency, including those with cystic fibrosis or post‑surgical pancreatic loss.
GNH India supplies Mezym as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Mezym provides pancreatic enzyme replacement therapy for conditions affecting exocrine pancreatic function.

  • Exocrine pancreatic insufficiency: improves nutrient absorption and reduces steatorrhea.
  • Cystic fibrosis‑related pancreatic insufficiency: supports digestion and growth in affected individuals.
  • Post‑pancreatic resection insufficiency: aids digestion after surgical removal of pancreatic tissue.

How It Works

  • Pancreas Powder supplies exogenous pancreatic enzymes—including lipase, amylase, and proteases—that act in the duodenum to hydrolyze dietary fats, carbohydrates, and proteins. By supplementing the deficient endogenous enzymes, it restores normal digestive processes and enhances nutrient absorption in patients with impaired pancreatic exocrine function.

Side Effects

Pancreatic enzyme replacement can be associated with a range of adverse reactions.

Common Side Effects

  • Abdominal discomfort or cramping.
  • Flatulence or bloating.
  • Diarrhea or loose stools.
  • Nausea or mild vomiting.
  • Constipation.
  • Unpleasant taste or oral irritation.

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, or swelling.
  • Severe abdominal pain indicating possible pancreatitis.
  • Intestinal obstruction or ileus.
  • Necrotizing colitis.
  • Anaphylaxis (rare).

Precautions & Warnings

When prescribing Mezym, consider the following precautions to ensure safe use.

  • Dose adjustment: tailor the enzyme dose to the individual’s clinical response and nutritional needs.
  • Renal impairment: monitor patients with reduced kidney function for accumulation of enzyme fragments.
  • Allergic history: assess for known hypersensitivity to porcine or bovine pancreatic extracts.
  • Concomitant antacids: be aware that some antacids may reduce enzyme activity; timing of administration may need adjustment.
  • Nutritional monitoring: regularly evaluate weight, vitamin levels, and stool fat content.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Pancreatic enzyme preparations can interact with other oral medications, affecting their absorption or activity.

Major Interactions (Avoid)

  • Bile acid sequestrants (e.g., cholestyramine): may bind enzymes and reduce efficacy.
  • High‑dose proton pump inhibitors: can alter gastric pH and affect enzyme activation, requiring dose reassessment.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may interfere with enzyme activity; separate dosing by at least 30 minutes.
  • Oral contraceptives: theoretical reduction in absorption; monitor for efficacy.
  • Antibiotics with poor oral absorption (e.g., tetracycline): may have reduced bioavailability when taken with enzymes.

Frequently Asked Questions

Mezym is used as a pancreatic enzyme replacement therapy to aid digestion in patients with exocrine pancreatic insufficiency, including those with cystic fibrosis or who have had part of their pancreas removed. It helps break down fats, proteins, and carbohydrates, reducing malabsorption and related symptoms such as steatorrhea.

Pancreas Powder contains a blend of lipase, amylase, and protease enzymes that mimic the natural pancreatic secretions. When taken orally, the enzymes become active in the small intestine, where they hydrolyze dietary fats, carbohydrates, and proteins, facilitating their absorption and improving nutritional status.

The dose of Mezym is individualized and determined by the prescribing healthcare professional based on the patient’s age, weight, severity of pancreatic insufficiency, and dietary fat intake. Patients should follow the prescriber’s instructions and adjust the dose only under medical supervision.

Safety data for Mezym in pregnancy and lactation are limited. The prescriber should evaluate the potential benefits against any possible risks before recommending use in pregnant or nursing individuals. If prescribed, it should be used only when clearly needed.

To order Mezym, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Mezym provides a broad spectrum of pancreatic enzymes similar to other enzyme replacement therapies such as Creon or Pancreaze. Differences may lie in enzyme activity units, formulation (powder vs. capsule), and manufacturing origin. Clinicians choose a product based on patient tolerance, dosing flexibility, and cost considerations.

Mezym should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture, heat, and direct sunlight. Do not store in the refrigerator or freezer unless specifically instructed by the manufacturer.

Mezym is taken orally, usually with meals or snacks that contain fat, to ensure the enzymes mix with ingested food in the gastrointestinal tract. The tablets or powder should be swallowed whole with a sufficient amount of water, following the dosing schedule prescribed by the healthcare provider.

Serious risks include allergic reactions such as rash, swelling, or anaphylaxis, and rare events like severe abdominal pain indicating pancreatitis or intestinal obstruction. Patients should seek immediate medical attention if they experience any signs of a severe reaction or unexplained gastrointestinal distress.

Mezym should not be used by individuals with a known hypersensitivity to porcine or bovine pancreatic extracts or any other component of the formulation. It is also contraindicated in patients with active gastrointestinal obstruction or severe inflammatory bowel disease until the condition is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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