Product image of Mezym (Pancreas Powder From Porcine) supplied by GNH India

Mezym

Active Ingredient:
Pancreas Powder From Porcine
Origin:
EU

Mezym (Pancreas Powder From Porcine)

Pancreas powder from porcine, the active ingredient in Mezym, is a digestive enzyme presented as a powder for oral use. It treats exocrine pancreatic insufficiency and related conditions in patients with cystic fibrosis, chronic pancreatitis, or other causes of pancreatic enzyme deficiency.

GNH India supplies Mezym as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Uab Berlin Chemie Menarini Baltic

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Indications & Clinical Uses

Mezym provides exogenous pancreatic enzymes to support digestion in disorders characterized by exocrine pancreatic insufficiency.

  • Exocrine pancreatic insufficiency: improves digestion and nutrient absorption.
  • Cystic fibrosis: aids breakdown of fats, proteins, and carbohydrates, reducing malabsorption.
  • Chronic pancreatitis: supplements deficient pancreatic enzymes to alleviate steatorrhea and weight loss.

How It Works

  • Mezym contains a mixture of porcine-derived amylase, lipase and proteases. After oral administration, the powder releases these enzymes in the duodenum where they hydrolyze carbohydrates, fats and proteins, respectively, facilitating their absorption and compensating for the patient's deficient endogenous pancreatic secretions.

Side Effects

Mezym may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Abdominal discomfort: mild pain or cramping after ingestion.
  • Flatulence: increased gas production.
  • Nausea: feeling of queasiness.
  • Oily or fatty stools: steatorrhea due to unabsorbed fat.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Severe abdominal pain: may indicate pancreatitis exacerbation.
  • Respiratory distress: difficulty breathing or wheezing.
  • Serum sickness–like reaction: fever, joint pain, and rash.
  • Persistent diarrhea: leading to dehydration and electrolyte imbalance.

Precautions & Warnings

Before using Mezym, consider the following precautions.

  • Dose adjustment: may be required in patients with renal or hepatic impairment.
  • Allergy assessment: avoid if known hypersensitivity to porcine proteins.
  • Monitoring: watch for signs of malabsorption or fat‑soluble vitamin deficiency.
  • Drug interactions: consider concomitant acid‑suppressing therapy which may reduce enzyme activation.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Mezym can interact with other medications that affect gastric acidity or bind proteins.

Major Interactions (Avoid)

  • Proton pump inhibitors: may reduce enzyme activation in the acidic environment.
  • Antacids containing aluminum or magnesium: can bind enzymes and lower their activity.

Moderate Interactions (Monitor Closely)

  • Orlistat: may interfere with fat digestion and enzyme efficacy.
  • Cholestyramine: can bind enzymes and reduce their activity.
  • High‑dose vitamin supplements: may affect enzyme function or absorption.

Frequently Asked Questions

Mezym is used to replace deficient pancreatic enzymes in patients with exocrine pancreatic insufficiency, including those with cystic fibrosis, chronic pancreatitis, or other conditions that impair natural enzyme production. By providing amylase, lipase and proteases, it helps improve digestion of carbohydrates, fats and proteins, supporting better nutrient absorption.

The porcine pancreas powder in Mezym contains a blend of digestive enzymes—amylase, lipase and proteases—that are released in the small intestine. These enzymes catalyze the breakdown of carbohydrates, fats and proteins into absorbable units, compensating for the patient’s insufficient endogenous pancreatic secretion and reducing malabsorption symptoms.

The appropriate dose of Mezym is individualized and determined by the prescribing healthcare professional based on the patient’s age, weight, severity of enzyme deficiency, and dietary fat content. Patients should follow the prescriber’s instructions and adjust the dose only under medical supervision.

Safety data for Mezym during pregnancy or lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should evaluate the risk‑benefit profile and discuss alternatives with the patient.

To order Mezym, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Mezym is a porcine‑derived enzyme powder, offering a broad spectrum of amylase, lipase and proteases similar to other pancreatic enzyme replacement therapies. Compared with enteric‑coated capsules, the powder can be mixed with food for flexible dosing, but both formulations aim to achieve comparable digestive support when used as directed.

Store Mezym at ambient temperature, preferably below 25 °C, in its original container to protect it from moisture and direct sunlight. Keep the container tightly closed after each use and avoid exposure to high humidity, which could affect enzyme activity.

Mezym is taken orally, typically mixed with a small amount of soft food or liquid immediately before or during a meal. The exact timing and amount should follow the prescribing clinician’s guidance to match the enzyme dose with the fat content of the meal.

Serious risks include allergic reactions such as rash, swelling, or anaphylaxis, and severe abdominal pain that may signal pancreatitis exacerbation. Patients should seek immediate medical attention if they experience difficulty breathing, persistent vomiting, or intense abdominal discomfort.

Mezym should not be used by individuals with a known hypersensitivity to porcine proteins or any of its excipients. Patients with severe gastrointestinal disorders that affect absorption, or those who have had a recent allergic reaction to pancreatic enzyme products, should avoid using Mezym unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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