Mezym (Pancreas Powder From Porcine)

• Mezym is a pancreatic enzyme preparation used to support digestion in conditions where endogenous pancreatic secretion is deficient.
• Exocrine pancreatic insufficiency: improves absorption of fats, proteins and carbohydrates, reducing steatorrhea.
• Cystic fibrosis: provides essential digestive enzymes to manage malabsorption and maintain nutritional status.
• Chronic pancreatitis: assists in digestion when pancreatic function is compromised.
• Pancreatic resection: replaces lost pancreatic enzymes after surgical removal of pancreatic tissue.

• Pancreas Powder From Porcine contains a mixture of digestive enzymes—amylase, lipase and proteases—that act in the gastrointestinal tract. After oral administration, the enzymes survive gastric acidity and become active in the duodenum, where they hydrolyze carbohydrates, fats and proteins, facilitating nutrient absorption and reducing maldigestion associated with pancreatic insufficiency.

Adverse reactions may occur with any pancreatic enzyme preparation. Patients should be aware of both common and serious potential effects.

Common Side Effects

• Abdominal discomfort or cramping
• Flatulence or bloating
• Diarrhea or loose stools
• Nausea or mild vomiting
• Constipation
• Oily or fatty stools

Serious or Rare Side Effects

• Allergic reaction including rash, itching or swelling
• Severe abdominal pain or pancreatitis exacerbation
• Anaphylaxis
• Vomiting of blood or material resembling coffee grounds
• Unexplained weight loss despite adequate intake
• Persistent or worsening gastrointestinal bleeding

• Mezym should be used with caution and under medical supervision, especially in patients with additional health concerns.
• Dose adjustment: tailor dose in renal or hepatic impairment as directed by a clinician.
• Nutritional monitoring: regularly assess weight and vitamin levels.
• Allergy assessment: avoid if known hypersensitivity to porcine proteins.
• Administration with meals: take enzymes during each main meal and snack for optimal effect.
• Avoid in active pancreatitis: defer use until inflammation resolves.
• Store at ambient temperature: keep in the original container, protect from moisture and heat.

Pancreatic enzyme powders can interact with certain medications, affecting their absorption or efficacy.

Major Interactions (Avoid)

• Antacids containing aluminum or magnesium: may bind enzymes and reduce activity.
• Cholestyramine or other bile‑acid sequestrants: can sequester enzymes, decreasing effectiveness.
• High‑dose proton pump inhibitors: lower gastric acidity, potentially impairing enzyme activation.

Moderate Interactions (Monitor Closely)

• Oral contraceptives: possible reduced hormone absorption, monitor efficacy.
• Warfarin: monitor INR as gastrointestinal changes may affect vitamin K levels.
• Tetracycline antibiotics: may increase gastrointestinal irritation, observe for adverse GI symptoms.