Product image of Mg 5-Sulfat Amp. Drossapharm (Magnesium Sulfate Heptahydrate) supplied by GNH India

Mg 5-Sulfat Amp. Drossapharm

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Mg 5-Sulfat Amp. Drossapharm (Magnesium Sulfate Heptahydrate)

Magnesium Sulfate, the active ingredient in Mg 5‑Sulfat Amp. Drossapharm, is a magnesium salt presented as an intravenous ampoule for intravenous use. It replaces magnesium in patients with deficiency or at risk of electrolyte imbalance.

GNH India supplies Mg 5‑Sulfat Amp. Drossapharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Drossapharm Gmbh

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Indications & Clinical Uses

Magnesium sulfate is used to correct magnesium deficiency and related electrolyte disturbances.

  • Hypomagnesemia: restores normal serum magnesium levels.
  • Pre‑eclampsia/eclampsia: provides prophylactic magnesium to reduce the risk of seizures.
  • Torsades de pointes: stabilises cardiac repolarisation and helps prevent ventricular tachycardia.
  • Cardiac arrhythmias: corrects electrolyte imbalance that contributes to arrhythmic events.
  • Obstetric magnesium supplementation: supports maternal magnesium status during labour and delivery.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions, which act as essential cofactors for numerous enzymatic reactions, stabilise cell membranes, antagonise calcium influx, and modulate voltage‑gated ion channels. These actions help normalise neuronal excitability, vascular tone, and myocardial conduction, thereby correcting magnesium deficiency and its physiological consequences.

Side Effects

Adverse reactions may occur with intravenous magnesium administration.

Common Side Effects

  • Flushing or warmth at the infusion site.
  • Sweating or feeling of heat.
  • Nausea or mild vomiting.
  • Headache.
  • Hypotension.
  • Dizziness.

Serious or Rare Side Effects

  • Respiratory depression or arrest.
  • Severe hypotension leading to shock.
  • Hypermagnesemia with cardiac arrest or arrhythmia.
  • Profound muscle weakness or paralysis.
  • Anaphylactic or severe allergic reaction.
  • Cardiac conduction block.

Precautions & Warnings

Magnesium sulfate should be used with caution in specific clinical situations.

  • Renal impairment: monitor serum magnesium and adjust infusion rate.
  • Cardiac conduction disorders: avoid rapid infusion in patients with AV block.
  • Neuromuscular disease: may exacerbate muscle weakness.
  • Electrolyte monitoring: check calcium and potassium levels regularly.
  • Concomitant use with other magnesium‑containing products: risk of hypermagnesemia.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Magnesium sulfate can interact with several drug classes.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged paralysis.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increased renal magnesium loss.
  • ACE inhibitors or ARBs: may alter renal handling of magnesium.

Frequently Asked Questions

Mg 5‑Sulfat Amp. Drossapharm is an intravenous magnesium sulfate preparation used to treat hypomagnesemia, provide prophylaxis in pre‑eclampsia/eclampsia, manage certain cardiac arrhythmias such as torsades de pointes, and support magnesium status during obstetric procedures.

Magnesium sulfate supplies Mg2+ ions that serve as cofactors for many enzymatic reactions, stabilise cell membranes, antagonise calcium entry, and modulate voltage‑gated ion channels. These actions help normalise neuromuscular transmission, vascular tone, and cardiac electrophysiology, thereby correcting magnesium deficiency.

The appropriate dose of magnesium sulfate is determined by the prescribing clinician based on the patient’s clinical condition, serum magnesium level, and therapeutic goal. Dosing regimens vary widely, so the prescriber sets the exact amount and infusion rate.

Magnesium sulfate is commonly used in obstetrics for seizure prophylaxis in pre‑eclampsia and eclampsia, and its safety profile in pregnancy is well established. However, the product’s specific pregnancy category is listed as unknown, and clinicians should weigh benefits against any potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Magnesium sulfate uniquely provides magnesium ions, which are essential for over 300 enzymatic processes and for stabilising cardiac and neuromuscular function. Unlike sodium or potassium salts, it specifically corrects magnesium deficiency and has a direct role in preventing seizures in pre‑eclampsia, making it the preferred choice when magnesium repletion is required.

The ampoules should be stored at ambient temperature, away from direct sunlight and moisture. Keep them in the original packaging until use, and avoid exposing them to extreme temperatures or physical shock that could compromise the glass container.

Mg 5‑Sulfat Amp. Drossapharm is administered intravenously. The ampoule is added to a compatible IV fluid or given as a direct IV push, following the prescriber’s instructions regarding infusion rate, concentration and monitoring parameters.

Serious adverse events include respiratory depression, severe hypotension, cardiac arrest, hypermagnesemia‑induced arrhythmias, profound muscle weakness and anaphylactic reactions. Continuous monitoring of vital signs and serum magnesium levels is essential during infusion, especially in patients with renal or cardiac impairment.

Magnesium sulfate is contraindicated in patients with known hypersensitivity to magnesium salts, severe renal failure where clearance is impaired, and in those with existing severe heart block or profound hypotension unless under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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