Product image of Mg 5-Sulfat Amp. Drossapharm Gmbh (Magnesium Sulfate Heptahydrate) supplied by GNH India

Mg 5-Sulfat Amp. Drossapharm Gmbh

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Mg 5-Sulfat Amp. Drossapharm Gmbh (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Mg 5-Sulfat Amp. Drossapharm Gmbh, is a magnesium salt presented as an ampoule for injection for intramuscular and intravenous use. It is employed to correct low magnesium levels and to manage obstetric and cardiac emergencies.
GNH India supplies Mg 5-Sulfat Amp. Drossapharm Gmbh as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Drossapharm Gmbh

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Indications & Clinical Uses

Magnesium sulfate is used in clinical situations that require rapid electrolyte correction or vascular smooth‑muscle relaxation.

  • Hypomagnesemia: restores normal serum magnesium concentrations.
  • Eclampsia and pre‑eclampsia: prevents seizures and stabilises blood pressure in pregnant patients.
  • Cardiac arrhythmias (e.g., torsades de pointes): helps normalize cardiac rhythm.
  • Constipation: acts as an osmotic laxative to promote bowel movements.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that compete with calcium at voltage‑gated channels, reducing calcium influx and causing smooth‑muscle relaxation and vasodilation. The ion also stabilises neuronal membranes, decreasing excitability, and serves as a co‑factor for numerous enzymatic reactions involved in ATP metabolism and electrolyte balance.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Flushing or warmth at the injection site
  • Nausea or vomiting
  • Headache
  • Hypotension
  • Dizziness
  • Muscle weakness

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypotension or cardiovascular collapse
  • Hypermagnesemia leading to cardiac arrest
  • Anaphylactic reaction
  • Tissue necrosis at the injection site
  • Cardiac arrhythmias due to excessive magnesium levels

Precautions & Warnings

When using magnesium sulfate, clinicians should consider patient‑specific factors and monitor for complications.

  • Renal impairment: assess serum magnesium and adjust dose accordingly.
  • Cardiac disease: use cautiously in patients with conduction abnormalities.
  • Neuromuscular disorders: avoid or monitor in myasthenia gravis.
  • Pregnancy: evaluate risk‑benefit, especially in the third trimester.
  • Concomitant calcium channel blockers: monitor for additive hypotensive effects.
  • Store below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Magnesium sulfate can interact with several medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Calcium channel blockers: additive vasodilatory and hypotensive actions.
  • Neuromuscular blocking agents: prolonged muscle relaxation.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increased renal magnesium loss.
  • ACE inhibitors or ARBs: potential impact on renal function.
  • Certain antibiotics (e.g., tetracyclines): may form complexes, reducing efficacy when given concurrently.

Frequently Asked Questions

Mg 5‑Sulfat Amp. Drossapharm contains magnesium sulfate, which is used to correct low magnesium levels, prevent seizures in eclampsia or pre‑eclampsia, treat certain cardiac arrhythmias such as torsades de pointes, and act as an osmotic laxative for constipation.

Magnesium sulfate releases Mg2+ ions that act as calcium antagonists, reducing calcium entry into cells. This leads to smooth‑muscle relaxation, vasodilation, and stabilization of neuronal membranes, while also serving as a co‑factor for many enzymatic processes that maintain electrolyte and energy balance.

The appropriate dose is determined by the prescribing clinician based on the patient’s condition, serum magnesium level, weight, and route of administration. Healthcare professionals adjust the regimen to achieve therapeutic goals while avoiding toxicity.

Magnesium sulfate is commonly used in obstetric care, especially for eclampsia prevention, but its safety depends on gestational age and clinical context. Clinicians weigh benefits against potential risks, and breastfeeding mothers should consult a healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with potassium or calcium salts, magnesium sulfate uniquely addresses magnesium deficiency and provides vasodilatory and anticonvulsant effects. It is preferred in obstetric emergencies and specific cardiac arrhythmias, whereas other electrolytes target different physiologic deficits.

Mg 5‑Sulfat Amp. Drossapharm should be stored below 25 °C, in its original sealed ampoule, protected from moisture and direct light. Do not freeze the product, and handle with aseptic technique to maintain sterility.

The ampoule is intended for intramuscular or intravenous injection. Administration is performed by qualified healthcare personnel using aseptic technique, with the dose and rate determined by the prescriber according to the clinical indication.

Serious risks include hypermagnesemia, which can cause respiratory depression, severe hypotension, cardiac arrest, and neuromuscular blockade. Prompt monitoring of serum magnesium and clinical signs is essential, especially in patients with renal impairment or when high doses are used.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure, advanced heart block without a pacemaker, or myasthenia gravis should generally avoid this medication unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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