Product image of Mg Magnesiumsulfatheptahydrat (Magnesium Sulfate Heptahydrate) supplied by GNH India

Mg Magnesiumsulfatheptahydrat

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Mg Magnesiumsulfatheptahydrat (Magnesium Sulfate Heptahydrate)

Magnesium sulfate heptahydrate, the active ingredient in Mg Magnesiumsulfatheptahydrat, is a magnesium salt presented as an injectable solution for intramuscular and intravenous use. It addresses magnesium deficiency and is employed in the management of eclampsia, severe cardiac arrhythmias, and asthma exacerbations.

GNH India supplies Mg Magnesiumsulfatheptahydrat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Inresa Arzneimittel Gmbh

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Indications & Clinical Uses

Magnesium sulfate heptahydrate is used in several electrolyte‑related and cardiovascular conditions:

  • Magnesium deficiency: restores normal serum magnesium concentrations.
  • Eclampsia/preeclampsia: prevents and treats seizures in pregnant patients.
  • Severe cardiac arrhythmias (e.g., torsades de pointes): stabilises cardiac electrical activity.
  • Bronchial asthma exacerbations: promotes bronchodilation and reduces airway hyper‑responsiveness.

How It Works

  • Magnesium sulfate heptahydrate dissociates to release Mg2+ ions that serve as essential cofactors for numerous enzymatic reactions, stabilize cell membranes, and competitively antagonise calcium at voltage‑gated channels. This calcium antagonism produces vasodilation, reduces neuromuscular excitability, and exerts anti‑arrhythmic effects, while the electrolyte replenishment corrects magnesium deficits.

Side Effects

Adverse reactions may vary with dose and route of administration.

Common Side Effects

  • Flushing: sensation of warmth and redness.
  • Sweating: increased perspiration.
  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Hypotension: modest reduction in blood pressure.
  • Dizziness: light‑headed feeling.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort.
  • Cardiac arrest: loss of effective heart activity.
  • Severe hypotension: marked drop in blood pressure.
  • Hypermagnesemia: excessive serum magnesium causing neuromuscular weakness.
  • Anaphylaxis: acute allergic reaction.
  • Arrhythmia worsening: paradoxical cardiac rhythm disturbances.

Precautions & Warnings

Magnesium sulfate heptahydrate requires careful clinical monitoring.

  • Renal impairment: monitor serum magnesium and adjust dosing.
  • Cardiac disease: use cautiously in patients with conduction abnormalities.
  • Neuromuscular disorders: observe for increased muscle weakness.
  • Pregnancy: limited safety data; weigh maternal benefit against fetal risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate heptahydrate can alter the effects of several drugs.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged paralysis.
  • Potassium‑sparing diuretics: heightened risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Aminoglycoside antibiotics: may enhance neuromuscular blockade.
  • ACE inhibitors: potential for increased hypotension.
  • Other magnesium‑containing products: cumulative magnesium load.

Frequently Asked Questions

Mg Magnesiumsulfatheptahydrat is an injectable magnesium salt used to correct magnesium deficiency, prevent and treat eclampsia/preeclampsia in pregnancy, manage severe cardiac arrhythmias such as torsades de pointes, and aid in the treatment of bronchial asthma exacerbations.

The compound releases magnesium ions that act as cofactors for many enzymes, stabilize cell membranes, and antagonise calcium at voltage‑gated channels. This results in vasodilation, reduced neuromuscular excitability, and anti‑arrhythmic activity while replenishing depleted magnesium stores.

The specific dose and infusion rate are determined by the prescribing clinician based on the indication, patient weight, renal function and clinical response. Healthcare professionals should follow local guidelines and product labeling when prescribing.

Safety data in pregnancy are limited; the drug is used when the potential maternal benefit outweighs any possible risk to the fetus, particularly for eclampsia management. Breastfeeding considerations should be discussed with a healthcare provider, as magnesium can be excreted in milk.

Enquiries are submitted via the product page on gnhindia.com, where the required quantity is entered. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Magnesium sulfate heptahydrate is the most widely used injectable magnesium salt, offering rapid bioavailability and predictable pharmacokinetics. Compared with oral magnesium salts, it provides faster correction of severe deficiency and is preferred in acute settings such as eclampsia or life‑threatening arrhythmias.

The product should be stored at 2‑8 °C in a refrigerator, protected from light. It must not be frozen or shaken vigorously. Once removed from refrigeration, use within the time frame specified in the product label.

It is administered by intramuscular or intravenous injection under aseptic conditions. The route, infusion speed and total dose are determined by the treating physician according to the clinical indication and patient-specific factors.

Serious risks include respiratory depression, severe hypotension, hypermagnesemia leading to neuromuscular weakness or cardiac arrest, and rare anaphylactic reactions. Continuous monitoring of vital signs and serum magnesium levels is essential during high‑dose therapy.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without appropriate monitoring, and those with existing profound hypotension or heart block should not receive this medication unless benefits clearly outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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