Product image of Mgd 400 Direct Ee (Magnesium Oxide, Heavy, Magnesium Citrate Dibasic) supplied by GNH India

Mgd 400 Direct Ee

Active Ingredient:
Magnesium Oxide, Heavy, Magnesium Citrate Dibasic
Origin:
EU

Mgd 400 Direct Ee (Magnesium Oxide, Heavy, Magnesium Citrate Dibasic)

Magnesium oxide, the active ingredient in Mgd 400 Direct Ee, is a mineral supplement presented as an oral tablet for oral use. It is employed to treat magnesium deficiency and related electrolyte disturbances in adults and supports normal neuromuscular and cardiovascular function.

GNH India supplies Mgd 400 Direct Ee as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with consistent quality and regulatory compliance.

Manufacturer / TM Owner

Protina Pharmazeutische Gesellschaft Mbh

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Indications & Clinical Uses

Mgd 400 Direct Ee is used to address conditions associated with low magnesium levels.

  • Magnesium deficiency: restores normal magnesium stores and supports enzymatic processes.
  • Hypomagnesemia: raises serum magnesium concentration to therapeutic range.
  • Post‑operative care: helps maintain electrolyte balance during recovery.
  • Pregnancy‑related magnesium loss: supplements maternal magnesium needs.

How It Works

  • Magnesium oxide and magnesium citrate dibasic dissociate in the gastrointestinal tract, releasing magnesium ions. These ions act as essential cofactors for over 300 enzymatic reactions, including ATP synthesis, protein formation, and nucleic acid stability. By increasing extracellular magnesium, the supplement helps regulate neuromuscular excitability, vascular tone, and cardiac electrophysiology, thereby correcting electrolyte imbalances.

Side Effects

Adverse reactions may occur with magnesium supplementation, ranging from mild gastrointestinal symptoms to rare systemic events.

Common Side Effects

  • Diarrhea
  • Abdominal cramping
  • Nausea
  • Flatulence
  • Constipation
  • Metallic taste

Serious or Rare Side Effects

  • Hypermagnesemia
  • Severe allergic reaction (anaphylaxis)
  • Cardiac arrhythmia
  • Muscle weakness
  • Low blood pressure
  • Respiratory depression

Precautions & Warnings

Use of magnesium supplements requires attention to certain health conditions and handling practices.

  • Renal impairment: monitor serum magnesium and adjust dose.
  • Cardiac disease: use caution due to potential effects on conduction.
  • Concurrent laxative use: may increase magnesium absorption.
  • Pregnancy: safety not established; consult a healthcare provider.
  • Drug interactions: review concomitant medications.
  • Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Magnesium can interact with several medications, affecting absorption or physiological effects.

Major Interactions (Avoid)

  • Antacids containing aluminum or calcium: may reduce magnesium absorption.
  • Tetracycline or fluoroquinolone antibiotics: chelation reduces efficacy.
  • Bisphosphonates: concurrent use impairs absorption.

Moderate Interactions (Monitor Closely)

  • Loop or thiazide diuretics: may increase risk of hypermagnesemia.
  • ACE inhibitors or ARBs: monitor blood pressure and electrolytes.
  • Cardiac glycosides: magnesium levels can affect toxicity.

Frequently Asked Questions

Mgd 400 Direct Ee is an oral magnesium supplement used to correct magnesium deficiency, treat hypomagnesemia, and support normal electrolyte balance in adults.

Magnesium oxide releases magnesium ions after dissolution, which act as cofactors for many enzymatic reactions, helping regulate neuromuscular activity, cardiac function, and energy metabolism.

The appropriate dose is determined by the prescribing healthcare professional based on the individual’s clinical condition, laboratory values, and overall health status.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning pregnancy, or breastfeeding should consult their healthcare provider before using the product.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mgd 400 Direct Ee combines magnesium oxide and magnesium citrate dibasic, offering both a high elemental magnesium content and good bioavailability, whereas some alternatives may contain only one magnesium salt, affecting absorption rates and gastrointestinal tolerance.

Store at room temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, direct sunlight, and excessive heat to maintain potency.

The product is taken orally, usually with water. It can be swallowed with or without food, following the dosage instructions provided by the prescriber.

The most serious risks include hypermagnesemia, which can cause cardiac arrhythmias, severe hypotension, respiratory depression, and, in rare cases, life‑threatening allergic reactions.

Individuals with severe renal impairment, known hypersensitivity to magnesium salts, or those on medications that may cause dangerous electrolyte shifts should avoid using this supplement unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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