Product image of Miacalcic (Calcitonin) supplied by GNH India

Miacalcic

Active Ingredient:
Calcitonin
Origin:
EU

Miacalcic (Calcitonin)

Calcitonin, the active ingredient in Miacalcic, is a hormone (calcitonin analog) presented as an injectable solution for intramuscular and subcutaneous use. It is employed to manage bone metabolism disorders such as osteoporosis, Pagets disease of bone, and hypercalcemia of malignancy, and to help prevent skeletal complications under medical supervision.

GNH India supplies Miacalcic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across regions.

Manufacturer / TM Owner

Essential Pharma (M) Limited

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Indications & Clinical Uses

Miacalcic (calcitonin) acts on bone metabolism and calcium regulation pathways.

  • Osteoporosis: reduces bone resorption and helps maintain bone density.
  • Pagets disease of bone: normalizes abnormal bone remodeling and lowers elevated alkaline phosphatase.
  • Hypercalcemia of malignancy: lowers serum calcium by inhibiting osteoclast activity and enhancing renal calcium excretion.

How It Works

  • Calcitonin binds to specific calcitonin receptors on osteoclasts, inhibiting their activity and thereby decreasing bone resorption. This action reduces the release of calcium from bone into the bloodstream. Additionally, calcitonin promotes renal calcium excretion, contributing to lower serum calcium levels and helping restore calcium homeostasis in affected patients.

Side Effects

Calcitonin may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Flushing: transient warmth and redness of the skin.
  • Headache: mild to moderate intensity.
  • Dizziness: occasional light‑headed sensation.
  • Injection site reactions: pain, erythema, or swelling at the site.
  • Mild hypotension: temporary drop in blood pressure.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Severe hypotension: marked blood pressure decline.
  • Hypocalcemia: clinically significant low serum calcium.
  • Osteosarcoma: rare malignant bone tumor reported with long‑term use.
  • Acute allergic reactions: rash, bronchospasm, or angioedema.
  • Severe injection site necrosis: tissue damage at the injection site.

Precautions & Warnings

When using Miacalcic, consider the following precautions.

  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown excretion; caution advised.
  • Renal impairment: monitor calcium levels and renal function.
  • Hypersensitivity: discontinue immediately if allergic reaction occurs.
  • Concomitant calcium supplements: may reduce therapeutic effect.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Calcitonin can interact with several medications.

Major Interactions (Avoid)

  • Calcium supplements: may antagonize calcitonin’s calcium‑lowering effect.
  • Bisphosphonates: additive reduction of serum calcium can increase hypocalcemia risk.
  • Loop diuretics: enhance calcium loss, raising hypocalcemia potential.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase renal calcium excretion.
  • Corticosteroids: can affect bone metabolism and calcium balance.
  • Thyroid hormones: may alter calcium homeostasis requiring monitoring.

Frequently Asked Questions

Miacalcic contains calcitonin and is prescribed to treat conditions related to abnormal bone turnover and high calcium levels, specifically osteoporosis, Pagets disease of bone, and hypercalcemia of malignancy. It helps reduce bone resorption and lower serum calcium, supporting bone health in affected patients.

Calcitonin binds to calcitonin receptors on osteoclasts, the cells responsible for breaking down bone. This binding inhibits osteoclast activity, decreasing bone resorption and the release of calcium into the bloodstream. The hormone also promotes renal excretion of calcium, contributing to lower serum calcium concentrations.

The dosage of Miacalcic is individualized by the prescribing clinician based on the specific indication, patient characteristics, and clinical response. Healthcare professionals determine the appropriate strength, frequency, and route of administration, and patients should follow the prescriber’s instructions without deviation.

Safety data for calcitonin in pregnancy and lactation are limited. The product should only be used if the potential therapeutic benefit justifies any possible risk to the fetus or infant. Clinicians typically weigh the benefits against uncertainties and may consider alternative therapies when possible.

To request Miacalcic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain handling if needed), and import documentation.

The primary alternative for managing bone loss and hypercalcemia is the bisphosphonate class. Bisphosphonates also inhibit osteoclast‑mediated bone resorption but have a different mechanism and longer skeletal retention. Calcitonin offers a rapid, short‑acting effect and can be useful when bisphosphonates are contraindicated or not tolerated.

Miacalcic must be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. If temporary temperature excursions occur, discard the product to ensure safety and efficacy.

Miacalcic is supplied as an injectable solution for intramuscular or subcutaneous injection. Administration is performed by a qualified healthcare professional using aseptic technique. The injection site is typically the thigh, upper arm, or abdomen, depending on the chosen route and patient factors.

Serious adverse events include severe allergic reactions such as anaphylaxis, marked hypotension, clinically significant hypocalcemia, and, rarely, osteosarcoma with long‑term use. Patients should be instructed to seek immediate medical attention if they experience difficulty breathing, swelling, faintness, or persistent low calcium symptoms.

Miacalcic is contraindicated in individuals with known hypersensitivity to calcitonin or any excipients in the formulation. Caution is advised for patients with severe renal impairment, uncontrolled hypocalcemia, or a history of osteosarcoma. Pregnant or breastfeeding women should only use it when clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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